@article{fdi:010040638,
  title = {{S}pirolactone iridoids might be responsible for the antileishmanial activity of a {P}eruvian traditional remedy made with {H}imatanthus sucuuba ({A}pocynaceae)},
  author = {{C}astillo, {D}. and {A}revalo, {J}. and {H}errera, {F}. and {R}uiz, {C}. and {R}ojas, {R}. and {R}engifo, {E}. and {V}aisberg, {A}. and {L}ock, {O}. and {L}emesre, {J}ean-{L}oup and {G}ornitzka, {H}. and {S}auvain, {M}ichel},
  abstract = {{E}xtracts of seven medicinal plants used specifically against cutaneous leishmaniasis in the {M}adre de {D}ios region of {P}eru were evaluated in vitro against promastigote and axenic amastigote forms of {L}eishmania amazonensis. {O}ne of them showed interesting leishmanicidal activities ({IC}50 = 5 mu g/ml in amastigotes). {B}io-guided isolation of the stem bark's ethanol extract of {H}imatanthus sucuuba ({S}pruce ex {M}ull. {A}rg.) {W}oodson ({A}pocynaceae) afforded the spirolactone iridoids isoplumericin and plumericin. {T}he latter showed a reduction of macrophage infection similar to that of the reference drug {A}mphotericin {B} ({IC}50 = 0.9 and 1 mu {M}, respectively). {T}hese findings validate the traditional use of {H}imatanthus sucuuba in the treatment of cutaneous leishmaniasis ({U}ta) in {P}eru.},
  keywords = {{L}eishmania amazonensis ; {P}eru ; {H}imatanthus sucituba ; plumericin ; ethnomedicine ; axenic amastigotes},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {112},
  numero = {2},
  pages = {410--414},
  ISSN = {0378-8741},
  year = {2007},
  DOI = {10.1016/j.jep.2007.03.025},
  URL = {http://www.documentation.ird.fr/hor/fdi:010040638},
}