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Castillo D., Arevalo J., Herrera F., Ruiz C., Rojas R., Rengifo E., Vaisberg A., Lock O., Lemesre Jean-Loup, Gornitzka H., Sauvain Michel. Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae). Journal of Ethnopharmacology, 2007, 112 (2), p. 410-414. ISSN 0378-8741

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Lien direct chez l'éditeur doi:10.1016/j.jep.2007.03.025

TitreSpirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)
Année de publication2007
Type de documentArticle référencé dans le Web of Science : 000247359500030
AuteursCastillo D., Arevalo J., Herrera F., Ruiz C., Rojas R., Rengifo E., Vaisberg A., Lock O., Lemesre Jean-Loup, Gornitzka H., Sauvain Michel.
SourceJournal of Ethnopharmacology, 2007, 112 (2), p. 410-414. ISSN 0378-8741
RésuméExtracts of seven medicinal plants used specifically against cutaneous leishmaniasis in the Madre de Dios region of Peru were evaluated in vitro against promastigote and axenic amastigote forms of Leishmania amazonensis. One of them showed interesting leishmanicidal activities (IC50 = 5 mu g/ml in amastigotes). Bio-guided isolation of the stem bark's ethanol extract of Himatanthus sucuuba (Spruce ex Mull. Arg.) Woodson (Apocynaceae) afforded the spirolactone iridoids isoplumericin and plumericin. The latter showed a reduction of macrophage infection similar to that of the reference drug Amphotericin B (IC50 = 0.9 and 1 mu M, respectively). These findings validate the traditional use of Himatanthus sucuuba in the treatment of cutaneous leishmaniasis (Uta) in Peru.
LocalisationFonds IRD [F B010040638]
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