Aghokeng FobangAvelinauteurautIRDBailesE.auteurautLoulS.auteurautCourgnaudValérieauteurautIRDMpoudi NgoléE.auteurautSharpP. M.auteurautDelaporteEricauteurautIRDPeetersMartineauteurautIRDtextjournalArticletext/pdfborn digitalaccessMustached monkeys (Cercopithecus cephus), which form a significant component of primate bushmeat in west central Africa, are infected with simian immunodeficiency virus (SIVmus). We identified and genetically characterized five new SlVmus strains infecting wild living mustached monkeys from Cameroon. Phylogenetic analysis of partial pol sequences revealed that SlVmus strains form two distinct groups within the clade comprised of lentiviruses isolated from Cercopithecus nictitans (SIVgsn), Cercopithecus mona (SIVmon) and C cephus (SlVmus). Characterisation of three full-length SIVmus genomes confirmed the presence of two distinct lineages infecting mustached monkeys. These two variants of SIVmus, here designated SIVmus-1 and SIVmus-2, were isolated from animals sharing habitats within the same geographic region. Phylogenetic analyses showed that the diversification of SlVmus, SIVgsn and SIVmon involved inter-lineage recombination, and suggested that one of the SIVmus lineages likely resulted from cross-species transmission and recombination involving SIVmus and an as yet uncharacterized SIV. These results indicate that cross-species transmission and recombination play a major role in the evolution of primate lentiviruses among sympatric primate species.specializedSIVSIVmus 1SIVmus 2lentivirusprimatecross species transmissionrecombinationpolyspecific association052 360240741820070042-6822http://www.documentation.ird.fr/hor/fdi:01003797010.1016/j.virol.2006.10.048IRD BondyF B010037970http://www.documentation.ird.fr/hor/fdi:010037970http://www.documentation.ird.fr/intranet/publi/2007/06/010037970.pdfAccès réservé (Intranet de l'IRD)IRD - Base Horizon / Pleins textes2007-06-282010-08-04fdi:010037970<languageTerm authority="iso639-2b">fre</languageTerm>