@article{fdi:010037792,
  title = {{M}odelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance - art. no. 9},
  author = {{A}lexander, {N}. and {S}utherland, {C}. and {R}oper, {C}. and {C}iss{\'e}, {B}adara and {S}chellenberg, {D}.},
  abstract = {{B}ackground: {I}ntermittent preventive treatment ({IPT}) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance. {M}ethods: {T}he key model inputs are age-specific values for a) baseline anti-malarial dosing rate, b) parasite prevalence, and c) proportion of those treated with anti-malarials ( outside {IPT}) who are infected. {T}hese are used to estimate the immediate effect of {IPT} on the genetic coefficient of selection (s). {T}he scenarios modelled were year round {IPT} to infants in rural southern {T}anzania, and three doses at monthly intervals of seasonal {IPT} in {S}enegal. {R}esults: {I}n the simulated {T}anzanian setting, the model suggests a high selection pressure for drug resistance, but that {IPT}i would only increase this by a small amount (4.4%). {T}he percent change in s is larger if parasites are more concentrated in infants, or if baseline drug dosing is less common or less specific. {I}f children aged up to five years are included in the {T}anzanian scenario then the predicted increase in s rises to 31%. {T}he {S}enegalese seasonal {IPT} scenario, in children up to five years, results in a predicted increase in s of 16%. {C}onclusion: {T}here is a risk that the useful life of drugs will be shortened if {IPT} is implemented over a wide childhood age range. {O}n the other hand, {IPT} delivered only to infants is unlikely to appreciably shorten the useful life of the drug used.},
  keywords = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  pages = {{NIL}_1--{NIL}_6},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-9},
  URL = {http://www.documentation.ird.fr/hor/fdi:010037792},
}