Vanden Haesevelde M.M., Peeters Martine, Jannes G., Janssens W., Van der Groen G., Sharp P.M., Saman E. (1996). Sequence analysis of a highly divergent HIV-1 related lentivirus isolated from a wild captured chimpanzee. Virology, (221), p. 346-350. ISSN 0042-6822.
Titre du document
Sequence analysis of a highly divergent HIV-1 related lentivirus isolated from a wild captured chimpanzee
Année de publication
1996
Type de document
Article
Auteurs
Vanden Haesevelde M.M., Peeters Martine, Jannes G., Janssens W., Van der Groen G., Sharp P.M., Saman E.
Source
Virology, 1996,
(221), p. 346-350 ISSN 0042-6822
Two strains of simian immunodeficiency viruses (SIV) isolated from chimpanzees (SIVCPZ-GAB and SIVCPZ-GAB2) originating from Gabon have previously been genetically characterized and shown to belong phylogenetically to the same lineage as the human immunodeficiency virus type 1 (HIV-1). We describe the sequence analysis of a third HIV-1 related virus, SIVCPZ-ANT, isolated from a wild captured chimpanzee originating from Zaire. This virus displayed the same genetic organization as HIV-1 and was found to fall on the same lineage as HIV-1 and SIVCPZ-GAB. Protein sequence identity with SIVCPZ-GAB ranged from 72% (Pol) to 48% (Env) for the structural proteins, while a particularly divergent Vpu was found (only 25% identity to SIVCPZ-GAB). The V3 regions of the SIV-CPZ isolates were exceptionally conserved in contrast to the high divergence of V3 among HIV-1 isolates. However, SIVCPZ-ANT did not show a greater degree of sequence similarity with SIVCPZ-GAB than with HIV-1 isolates and represents a quite divergent outgroup of the HIV-1 lineage. Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic. (Résumé d'auteur)
