%0 Unpublished Work
%9 AP : Autres productions
%A Gonzalez, Jean-Paul
%T Epidemiology of filovirus infections in the République Centrafricaine : a risk study associated with subsistence activities : final report
%C Nakhonpathom
%D 1997
%L fdi:010015987
%G ENG
%I Mahidol University
%K FIEVRE HEMORRAGIQUE ; EPIDEMIOLOGIE ; SEROLOGIE ; PREVALENCE ; SEX RATIO ; SANG ; ECHANTILLONNAGE ; TEST ELISA ; PROJET DE RECHERCHE
%K VIRUS EBOLA ; VIRUS MARBURG
%K CENTRAFRIQUE
%K LOBAYE REGION
%P 78  multigr.
%U https://www.documentation.ird.fr/hor/fdi:010015987
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/griseli1/010015987.pdf
%W Horizon (IRD)
%X With the natural history of the #Filovirus$ family seemingly unknown, filovirus ecology and natural history are still a rudimentary field of research. When the present project started, monthes before the dramatic and well publicized Kikwit outbreak, filovirus were not of any acuality and our group was one of the few to maintain a filovirus specific field research activity. In order to investigate the maintenance cycle of filovirus in Central Africa, a study was conducted within the rain forest of the République Centrafricaine (RCA). An epidemiological study was directed to determine the frequency and distribution of filovirus seroprevalence in a selected human population. Using an ELISA test, serum samples from pygmy and non-pygmy populations were tested for Ebola-Zaïre and Marburg virus reacting antibodies. Positive sera for filovirus were found in all study groups. Within the Lobaye district, Pygmies appeared to have a higher seroprevalence against Ebola-Zaïre (12.8%) and Marburg (4.36%) virus antigens than non-pygmies (respectively 4.3% and 0.0% seropositivity). Pygmy females as an higher Ebola seroprevalence than males. In contrast, Marburg antibody reacting sera were detected more frequently in male (7.6%) than female (1.9%) pygmies. Moreover preliminary retrospective studies done of the wet and dry savannah showed a significantly (p<0.04) higher seroprevalence against Marburg virus (>11%) than the one observed in the forested area (<4%). During our study, a temporal increase of Ebola seroprevalence was observed within the Lobaye area. No risk factor was clearly identify regarding the use of natural resources of the forest which include hunting, gathering and fishing... (Résumé d'auteur)
%$ 052MALTRA04