%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Bibollet-Ruche, F.
%A Cuny, Gérard
%A Pourrut, Xavier
%A Brengues, Cécile
%A Galat-Luong, Anh
%A Galat, Gérard
%A Delaporte, Eric
%T Multiple spliced env and nef transcripts of simian immunodeficiency virus from West African green monkey (SIVagm-sab)
%D 1998
%L fdi:010013581
%G ENG
%J AIDS Research and Human Retroviruses
%@ 0889-2229
%K VIRUS ; POLYMORPHISME GENETIQUE ; MUTATION
%K SIV.VIRUS IMMUNODEFICIENCE SIMIENNE ; EXPRESSION GENETIQUE ; PATHOGENIE ; SINGE VERT
%K AFRIQUE DE L'OUEST
%N 6
%P 515-519
%R 10.1089/aid.1998.14.515
%U https://www.documentation.ird.fr/hor/fdi:010013581
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_49-50/010013581.pdf
%V 14
%W Horizon (IRD)
%X We have characterized the spliced transcripts of nef and envelope genes of SIVagm from African green monkey of the #sabaeus$ subspecies. Most of the transcripts we have studied, representing the most abundant mRNA species in our assay, have undergone a specific splicing event that removes a part of the trans-activation response (TAR) element. This region is predicted to form a stable secondary structure (four stem-loop elements in SIVagm-sab) that affects the trans-activation of viral gene expression by Tat and the translation of the viral transcripts. Contrary to what is observed in other viruses, in which this R-region splicing has also been described (e.g. , HIV-2), the LTR splicing in SIVagm-sab removes part of the first stem-loop and the following ones, nearly completely disrupting the TAR element secondary structure. Because LTR splicing seems to be a conserved feature among the strains we have characterized, these results suggest that this phenomenon could have important consequences for virus replication, pathogenicity, and latency. (Résumé d'auteur)
%$ 052MALTRA03