@article{fdi:010013581,
  title = {{M}ultiple spliced env and nef transcripts of simian immunodeficiency virus from {W}est {A}frican green monkey ({SIV}agm-sab)},
  author = {{B}ibollet-{R}uche, {F}. and {C}uny, {G}{\'e}rard and {P}ourrut, {X}avier and {B}rengues, {C}{\'e}cile and {G}alat-{L}uong, {A}nh and {G}alat, {G}{\'e}rard and {D}elaporte, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have characterized the spliced transcripts of nef and envelope genes of {SIV}agm from {A}frican green monkey of the #sabaeus$ subspecies. {M}ost of the transcripts we have studied, representing the most abundant m{RNA} species in our assay, have undergone a specific splicing event that removes a part of the trans-activation response ({TAR}) element. {T}his region is predicted to form a stable secondary structure (four stem-loop elements in {SIV}agm-sab) that affects the trans-activation of viral gene expression by {T}at and the translation of the viral transcripts. {C}ontrary to what is observed in other viruses, in which this {R}-region splicing has also been described (e.g. , {HIV}-2), the {LTR} splicing in {SIV}agm-sab removes part of the first stem-loop and the following ones, nearly completely disrupting the {TAR} element secondary structure. {B}ecause {LTR} splicing seems to be a conserved feature among the strains we have characterized, these results suggest that this phenomenon could have important consequences for virus replication, pathogenicity, and latency. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{VIRUS} ; {POLYMORPHISME} {GENETIQUE} ; {MUTATION} ; {SIV}.{VIRUS} {IMMUNODEFICIENCE} {SIMIENNE} ; {EXPRESSION} {GENETIQUE} ; {PATHOGENIE} ; {SINGE} {VERT} ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{AIDS} {R}esearch and {H}uman {R}etroviruses},
  volume = {14},
  numero = {6},
  pages = {515--519},
  ISSN = {0889-2229},
  year = {1998},
  DOI = {10.1089/aid.1998.14.515},
  URL = {https://www.documentation.ird.fr/hor/fdi:010013581},
}