@article{fdi:010011045,
  title = {{C}omparative safety and immunogenicity of an acellular versus whole- cell pertussis component of {D}iphteria-{T}etanus-{P}ertussis vaccines in senegalese infants},
  author = {{S}imondon, {F}ran{\c{c}}ois and {Y}am, {A}. and {G}agnepain, {J}.{Y}. and {W}assilak, {S}. and {D}anve, {B}. and {C}adoz, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} diphtheria and tetanus toxoid two-component acellular pertussis vaccine ({DT}a{P}), consisting of 25 microg glutaraldehyde-detoxified pertussis toxin ({PT}) and 25 microg native filamentous hemagglutinin ({FHA}), was compared with diphtheria and tetanus toxoid whole-cell pertussis vaccine ({DT}w{P}) in a randomized, double-blind manner in 286 {S}enegalese infants inoculated at two, four, and six months of age. {I}n infants receiving {DT}a{P} a significantly lower rate of local reactions, crying and fever was observed than in infants receiving {DT}w{P}. {O}ne month after the third dose, the geometric mean titres for {FHA} antibodies were higher in the {DT}a{P} group, whereas increases in {PT} antibody titres were higher in the {DT}w{P} group. {M}ore than 90% of the infants had a fourfold or more increase in antibodies to both {PT} and {FHA} with either vaccine. {D}iphtheria, tetanus, and polio antibody responses were also measured and found to be comparable between the two groups. {T}he results of this pilot study support the implementation of a field trial to compare the protective efficacy of these vaccines against pertussis in the same setting. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{VACCINATION} ; {ETUDE} {COMPARATIVE} ; {ENFANT} ; {DIPHTERIE} ; {DTAP} ; {DTWP} ; {TETANOS} ; {COQUELUCHE} ; {SENEGAL}},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {C}linical {M}icrobiology and {I}nfectious {D}iseases},
  volume = {15},
  numero = {12},
  pages = {927--932},
  year = {1996},
  URL = {https://www.documentation.ird.fr/hor/fdi:010011045},
}