Fournet Alain, Ferreira M.E., Rojas de Arias A., Torres de Ortiz S., Inchausti A., Yaluff G., Quilhot W., Fernandez E., Hidalgo M.E. (1997). Activity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis. Comparative Biochemistry and Physiology, 116C (1), p. 51-54. ISSN 0742-8413.
Titre du document
Activity of compounds isolated from chilean lichens against experimental cutaneous leishmaniasis
Année de publication
1997
Type de document
Article
Auteurs
Fournet Alain, Ferreira M.E., Rojas de Arias A., Torres de Ortiz S., Inchausti A., Yaluff G., Quilhot W., Fernandez E., Hidalgo M.E.
Source
Comparative Biochemistry and Physiology, 1997,
116C (1), p. 51-54 ISSN 0742-8413
Three secondary metabolites isolated from Chilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of Leishmania ssp. Pannarine and 1'-chloropannarine exhibited in vitro activity at 50 microg/ml and (+) usnic acid at 25 microg/ml. BALB/c mice infected with Leishmania amazonensis were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous injections (regimens of 28 mg of pentavalent antimony) for 15 days. The subcutaneous and oral treatments with (+) usnic did not produce any effect, but by intralesional administration we observed a significant effect that reduced by 43.34% the weight lesions and by 72.28% the parasites loads in infected footpads. (Résumé d'auteur)
