%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Leroy, V.
%A Msellati, Philippe
%A Lepage, P.
%A Batungwanayo, J.
%A Hitimana, D.G.
%A Taelman, H.
%A Bogaerts, J.
%A Boineau, F.
%A Van de Perre, P.
%A Simonon, A.
%A Salamon, R.
%A Dabis, F.
%T Four years of natural history of HIV-1 infection in African women : a prospective cohort study in Kigali (Rwanda), 1988-1993
%D 1995
%L fdi:010007718
%G ENG
%J Journal of Acquired of Immune Deficiency Syndromes and Human Retrovirology
%@ 0894-9255
%K SIDA ; EPIDEMIOLOGIE ; MORTALITE ; FEMME ; GROSSESSE ; MALADIES ASSOCIEES ; DIAGNOSTIC
%K TUBERCULOSE ; VIRUS HIV-1
%K RWANDA ; KIGALI
%N 4
%P 415-421
%U https://www.documentation.ird.fr/hor/fdi:010007718
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010007718.pdf
%V 9
%W Horizon (IRD)
%X Clinical features and mortality due to human immunodeficiency virus type-1 (HIV-1) infection in women are described as part of a prospective 4-year cohort study on perinatal transmission of HIV in Kigali, Rwanda. Two hundred fifteen HIV-positive (HIV+) and 216 HIV-negative (HIV-) pregnant women were enrolled at delivery between November 1988 and June 1989. Clinical information collected during systematic quarterly examinations was compared. HIV antibody tests were performed at delivery and CD4/CD8 lymphocyte counts at 15 days' postpartum. HIV- women who seroconverted during the follow-up period were excluded from the analysis of the comparison group starting at the date of seroconversion. At enrollment, all HIV+ women were asymptomatic for acquired immune deficiency syndrome (AIDS). Incidence of tuberculosis was 2.9 per 100 women-years (WY) after 4 years of follow-up in HIV+ women versus 0.2 per 100 WY among HIV- women (relative risk. 18.2% ; 95% confidence interval 2.4-137.0). Among HIV+ women, the incidence of AIDS was 3.5 per 100 WY. The mortality rate was 4.4 per 100 WY among HIV+ women versus 0.5 per 100 WY among HIV- women. Clinical AIDS was present in only half of the fatalities. Tuberculosis was a major cause of morbidity and mortality in these HIV+ African women. An early diagnosis and an appropriate treatment or prevention of tuberculosis should improve the quality of life of HIV-infected patients in Africa. (Résumé d'auteur)
%$ 052MALTRA03