Publications des scientifiques de l'IRD

Leroy V., Msellati Philippe, Lepage P., Batungwanayo J., Hitimana D.G., Taelman H., Bogaerts J., Boineau F., Van de Perre P., Simonon A., Salamon R., Dabis F. (1995). Four years of natural history of HIV-1 infection in African women : a prospective cohort study in Kigali (Rwanda), 1988-1993. Journal of Acquired of Immune Deficiency Syndromes and Human Retrovirology, 9 (4), p. 415-421. ISSN 0894-9255.

Titre du document
Four years of natural history of HIV-1 infection in African women : a prospective cohort study in Kigali (Rwanda), 1988-1993
Année de publication
1995
Type de document
Article
Auteurs
Leroy V., Msellati Philippe, Lepage P., Batungwanayo J., Hitimana D.G., Taelman H., Bogaerts J., Boineau F., Van de Perre P., Simonon A., Salamon R., Dabis F.
Source
Journal of Acquired of Immune Deficiency Syndromes and Human Retrovirology, 1995, 9 (4), p. 415-421 ISSN 0894-9255
Clinical features and mortality due to human immunodeficiency virus type-1 (HIV-1) infection in women are described as part of a prospective 4-year cohort study on perinatal transmission of HIV in Kigali, Rwanda. Two hundred fifteen HIV-positive (HIV+) and 216 HIV-negative (HIV-) pregnant women were enrolled at delivery between November 1988 and June 1989. Clinical information collected during systematic quarterly examinations was compared. HIV antibody tests were performed at delivery and CD4/CD8 lymphocyte counts at 15 days' postpartum. HIV- women who seroconverted during the follow-up period were excluded from the analysis of the comparison group starting at the date of seroconversion. At enrollment, all HIV+ women were asymptomatic for acquired immune deficiency syndrome (AIDS). Incidence of tuberculosis was 2.9 per 100 women-years (WY) after 4 years of follow-up in HIV+ women versus 0.2 per 100 WY among HIV- women (relative risk. 18.2% ; 95% confidence interval 2.4-137.0). Among HIV+ women, the incidence of AIDS was 3.5 per 100 WY. The mortality rate was 4.4 per 100 WY among HIV+ women versus 0.5 per 100 WY among HIV- women. Clinical AIDS was present in only half of the fatalities. Tuberculosis was a major cause of morbidity and mortality in these HIV+ African women. An early diagnosis and an appropriate treatment or prevention of tuberculosis should improve the quality of life of HIV-infected patients in Africa. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; EPIDEMIOLOGIE ; MORTALITE ; FEMME ; GROSSESSE ; MALADIES ASSOCIEES ; DIAGNOSTIC ; TUBERCULOSE ; VIRUS HIV-1
Description Géographique
RWANDA ; KIGALI
Localisation
Fonds IRD [F B010007718] ; Montpellier (Centre IRD)
Identifiant IRD
fdi:010007718
Contact