%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Okomo-Assoumou, M.C.
%A Daulouede, S.
%A Lemesre, Jean-Loup
%A N'Zila-Mouanda, Alexis
%A Vincendeau, P.
%T Correlation of high serum levels of tumor necrosis factor-alpha with disease severity in human african trypanosomiasis
%D 1995
%L fdi:010007702
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K MALADIE DU SOMMEIL ; EPIDEMIOLOGIE ; SEROLOGIE ; SYMPTOME
%K FACTEUR NECROSE TUMORALE ; PARASITEMIE
%K CONGO ; BOUENZA
%K BOKO SONGHO REGION
%N 5
%P 539-543
%U https://www.documentation.ird.fr/hor/fdi:010007702
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010007702.pdf
%V 53
%W Horizon (IRD)
%X The levels of tumor necrosis factor alpha (TNF-alpha) in sera from #Trypanosoma brucei gambiense$-infected patients from the endemic region of Boko Songho (Bouenza focus in Congo) were measured. An increase was observed in sera from patients (geometric mean = 53.75 pg/ml, n = 69) compared with control subjects from the same endemic area (6.72 pg/ml, n = 31). The patients were classified as being in the early (blood lymphatic) stage and late (meningo-encephalitic) stage of disease according to the presence of parasites and cells in cerebrospinal fluid (CSF). An increase in TNF-alpha was noted in late stage patients (68.42 pg/ml, n = 28) compared with early stage patients (43.68 pg/ml, n = 41). Those patients with fever, asthenia, and edema and those with neurologic signs had higher levels of TNF-alpha (89.36 pg/ml, n = 26) than others (38.07 pg/ml, n= 43). No differences in TNF-alpha levels were seen when trypanosomes were detected in one location (blood, lymph nodes, or CSF) or two or three locations. These data show that the levels of TNF-alpha in serum of #T. b. gambiense$-infected patients were correlated with disease severity (presence of signs of inflammation or presence of major neurologic signs) and indicate that TNF-alpha could be involved in some aspects of human african trypanosomiasis physiopathology. (Résumé d'auteur)
%$ 052GLOTRY02