@article{fdi:010007702,
  title = {{C}orrelation of high serum levels of tumor necrosis factor-alpha with disease severity in human african trypanosomiasis},
  author = {{O}komo-{A}ssoumou, {M}.{C}. and {D}aulouede, {S}. and {L}emesre, {J}ean-{L}oup and {N}'{Z}ila-{M}ouanda, {A}lexis and {V}incendeau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he levels of tumor necrosis factor alpha ({TNF}-alpha) in sera from #{T}rypanosoma brucei gambiense$-infected patients from the endemic region of {B}oko {S}ongho ({B}ouenza focus in {C}ongo) were measured. {A}n increase was observed in sera from patients (geometric mean = 53.75 pg/ml, n = 69) compared with control subjects from the same endemic area (6.72 pg/ml, n = 31). {T}he patients were classified as being in the early (blood lymphatic) stage and late (meningo-encephalitic) stage of disease according to the presence of parasites and cells in cerebrospinal fluid ({CSF}). {A}n increase in {TNF}-alpha was noted in late stage patients (68.42 pg/ml, n = 28) compared with early stage patients (43.68 pg/ml, n = 41). {T}hose patients with fever, asthenia, and edema and those with neurologic signs had higher levels of {TNF}-alpha (89.36 pg/ml, n = 26) than others (38.07 pg/ml, n= 43). {N}o differences in {TNF}-alpha levels were seen when trypanosomes were detected in one location (blood, lymph nodes, or {CSF}) or two or three locations. {T}hese data show that the levels of {TNF}-alpha in serum of #{T}. b. gambiense$-infected patients were correlated with disease severity (presence of signs of inflammation or presence of major neurologic signs) and indicate that {TNF}-alpha could be involved in some aspects of human african trypanosomiasis physiopathology. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{MALADIE} {DU} {SOMMEIL} ; {EPIDEMIOLOGIE} ; {SEROLOGIE} ; {SYMPTOME} ; {FACTEUR} {NECROSE} {TUMORALE} ; {PARASITEMIE} ; {CONGO} ; {BOUENZA} ; {BOKO} {SONGHO} {REGION}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {53},
  numero = {5},
  pages = {539--543},
  ISSN = {0002-9637},
  year = {1995},
  URL = {https://www.documentation.ird.fr/hor/fdi:010007702},
}