@article{fdi:010007698,
  title = {{D}ifferent genetic characteristics of {P}lasmodium falciparum isolates collected during successive clinical {M}alaria episodes in senegalese children},
  author = {{C}ontamin, {H}. and {F}andeur, {T}. and {R}ogier, {C}. and {B}onnefoy, {S}. and {K}onate, {L}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {M}ercereau-{P}uijalon, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} narrow epidemiologic survey was conducted during a four-month period of intense malaria transmission in {D}ielmo, a holoendemic {S}enegalese village. {L}ongitudinal clinical and parasitologic follow-up indicate that clinical malaria episodes always occurred after an abrupt increase in parasite densities. {P}olymerase chain reaction analysis of #{P}lasmodium falciparum$ parasites was carried out in blood samples collected longitudinally from 10 children who had experienced, several clinical episodes during this period. {O}ur data show that the genetic diversity of the parasites circulating in this village is very large. {T}he successive clinical episodes experienced by each child were caused by genetically distinct parasite populations that were recently inoculated and multiplied in an apparently unrestricted manner. {I}mportantly, the genetic characteristics of the parasite populations detected during phases of asymptomatic carriage differed from those causing a clinical episode, suggesting that the various factors that control of parasite growth in these children are strain-specific. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {EPIDEMIOLOGIE} ; {AGENT} {PATHOGENE} ; {GENETIQUE} {DE} {POPULATION} ; {POLYMORPHISME} {GENETIQUE} ; {VARIABILITE} {GENETIQUE} ; {EPIDEMIE} ; {PCR}.{REACTION} {DE} {POLYMERISATION} {EN} {CHAINE} ; {SENEGAL} ; {DIELMO}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {54},
  numero = {6},
  pages = {632--643},
  ISSN = {0002-9637},
  year = {1996},
  URL = {https://www.documentation.ird.fr/hor/fdi:010007698},
}