%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Schmeda-Hirschmann, G.
%A Razmilic, I.
%A Sauvain, Michel
%A Moretti, Christian
%A Munoz, V.
%A Ruiz, E.
%A Balanza, E.
%A Fournet, Alain
%T Antiprotozoal activity of jatrogrossidione from Jatropha grossidentata and jatrophone from Jatropha isabellii
%D 1996
%L fdi:010007085
%G ENG
%J Phytotherapy Research
%@ 0951-418X
%K LEISHMANIOSE ; MALADIE DE CHAGAS ; PARASITE ; TRAITEMENT MEDICAL ; LUTTE ; PLANTE MEDICINALE ; MEDICAMENT ; ETHNOMEDECINE ; COMPOSE ORGANIQUE ; EXTRACTION
%K TERPENE ; JATROGROSSIDIONE ; JATROPHONE ; ACTIVITE ANTIPROTOZOAIRE
%P 375-378
%R 10.1002/(SICI)1099-1573(199608)10:5<375::AID-PTR847>3.0.CO;2-#
%U https://www.documentation.ird.fr/hor/fdi:010007085
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010007085.pdf
%V 10
%W Horizon (IRD)
%X The activity of jatrogrossidione, the main diterpene of #Jatropha grossidentata$ and jatrophone from #Jatropha isabellii$ was determined against #Leishmania$ and #Trypanosoma cruzi$ strains in vitro as well as against #Leishmania amazonensis$ in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5-5.0 microg/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards #Leishmania$ strains were >100, 50-100 and 1 microg/mL, respectively. The IC50 of jatrogrossidione was <0.25 microg/mL against amastigote forms of #Leishmania$ infecting macrophages, with toxicity at concentrations higher than 0.5 microg/mL. BALB/c mice infected with #L. amazonensis$ strain PH 8 were treated 24 h after infection with jatrogrossidione and jatrophone for 13 consecutive days. Jatrophone at 25 mg/kg/day subcutaneously administered was significantly active (p<0.05) against the virulent strain PH 8 of #L. amazonensis$ ; it was more active than glucantime at 112 mg Sb per kg/day. Subcutaneous administration of jatrophone, however, proved to be too toxic under our assay conditions. Assays of single local treatment on the footpad infection 2 weeks after inoculation of #L. amazonensis$ indicated that jatrogrossidione and jatrophone were inactive at the selected doses. (Résumé d'auteur)
%$ 052PHLEIS03 ; 076PLAMED03