Publications des scientifiques de l'IRD

Schmeda-Hirschmann G., Razmilic I., Sauvain Michel, Moretti Christian, Munoz V., Ruiz E., Balanza E., Fournet Alain. (1996). Antiprotozoal activity of jatrogrossidione from Jatropha grossidentata and jatrophone from Jatropha isabellii. Phytotherapy Research, 10, p. 375-378. ISSN 0951-418X.

Titre du document
Antiprotozoal activity of jatrogrossidione from Jatropha grossidentata and jatrophone from Jatropha isabellii
Année de publication
1996
Type de document
Article
Auteurs
Schmeda-Hirschmann G., Razmilic I., Sauvain Michel, Moretti Christian, Munoz V., Ruiz E., Balanza E., Fournet Alain
Source
Phytotherapy Research, 1996, 10, p. 375-378 ISSN 0951-418X
The activity of jatrogrossidione, the main diterpene of Jatropha grossidentata and jatrophone from Jatropha isabellii was determined against Leishmania and Trypanosoma cruzi strains in vitro as well as against Leishmania amazonensis in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5-5.0 microg/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards Leishmania strains were >100, 50-100 and 1 microg/mL, respectively. The IC50 of jatrogrossidione was <0.25 microg/mL against amastigote forms of Leishmania infecting macrophages, with toxicity at concentrations higher than 0.5 microg/mL. BALB/c mice infected with L. amazonensis strain PH 8 were treated 24 h after infection with jatrogrossidione and jatrophone for 13 consecutive days. Jatrophone at 25 mg/kg/day subcutaneously administered was significantly active (p<0.05) against the virulent strain PH 8 of L. amazonensis ; it was more active than glucantime at 112 mg Sb per kg/day. Subcutaneous administration of jatrophone, however, proved to be too toxic under our assay conditions. Assays of single local treatment on the footpad infection 2 weeks after inoculation of L. amazonensis indicated that jatrogrossidione and jatrophone were inactive at the selected doses. (Résumé d'auteur)
Plan de classement
Lutte [052PHLEIS03] ; Substances naturelles : utilisation pharmacologique [076PLAMED03]
Descripteurs
LEISHMANIOSE ; MALADIE DE CHAGAS ; PARASITE ; TRAITEMENT MEDICAL ; LUTTE ; PLANTE MEDICINALE ; MEDICAMENT ; ETHNOMEDECINE ; COMPOSE ORGANIQUE ; EXTRACTION ; TERPENE ; JATROGROSSIDIONE ; JATROPHONE ; ACTIVITE ANTIPROTOZOAIRE
Localisation
Fonds IRD [F B010007085]
Identifiant IRD
fdi:010007085
Contact