@inproceedings{fdi:010007004,
  title = {{I}n vivo susceptibility of {P}lasmodium falciparum to chloroquine and amodiaquine in 1 to 15 years children in southern {C}ameroon},
  author = {{L}e {H}esran, {J}ean-{Y}ves and {B}oudin, {C}hristian and {P}ersonne, {P}. and {D}evries, {C}. and {C}hambon, {R}. and {F}oumane, {V}. and {F}ievet, {N}adine and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince 1985, chloroquine resistance ({CR}) became evident in {C}ameroon, and rapidly spread out over the country. {D}espite such a situation, chloroquine is still the first antimalarial drug. {CR} follow up was mostly carried out by in vivo tests among schoolchildren. {I}n this population, of a mean 9 yrs of age, a {CR} rate of 30 to 45% was reported. {H}owever, this may not show the true level of {CR}, because of the interaction of immunity in controlling parasite growth. {T}herefore, in southern {C}ameroon, we studied the activity of 25 mg/kg over 3 days of chloroquine and amodiaquine in treating asymptomatic children ranging from 1 to 15 yrs, with parasite density > 1000/microl. {F}ollowing chloroquine treatment, children with treatment failure by {D}7 in the 0-2, 3-4, 5-9 and 10-15 yrs age groups were : 26-37 (71%), 9/21 (43%), 24/43 (56%) and 12/30 (40%). {F}our infections were {RIII}, all in the 0-2 yrs group. 41 of the 60 children with a {D}7 negative blood smear were seen again at {D}14 : 19 of these (46%) were positive. {F}ollowing amodiaquine, children with treatment failure by {D}7 were : 3/28 (11%), 2/20 (10%), 1/17 (6%) and 0/6. {N}o {RIII} level was observed. 44 of the 65 children with {D}7 negative blood smear were seen on {D}14 : 7 (16%) had a positive blood smear, 5 being in the 0-2 yrs group. {T}he prevalence of {CR} in southern {C}ameroon is high, especially in young children. {T}he prevalence and level of {CR} decreased with age. {A}modiaquine is effective > 89% in all age groups, and might be considered as a first line treatment in young children. {M}edical practitioners must be provided with information on resistance within groups having not yet acquired premunition. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {CHIMIOPROPHYLAXIE} ; {TRAITEMENT} {MEDICAL} ; {SENSIBILITE} {RESISTANCE} ; {ENFANT} ; {CHLOROQUINE} ; {AMODIAQUINE} ; {CAMEROUN}},
  volume = {55},
  numero = {2},
  pages = {181},
  booktitle = {{P}rogram and abstract of the 45th annual {M}eeting of the {A}merican {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  year = {1996},
  URL = {https://www.documentation.ird.fr/hor/fdi:010007004},
}