Publications des scientifiques de l'IRD

Aaby Peter, Samb Badara, Andersen M., Simondon François. (1996). No long-term excess mortality after measles infection : a community study from Senegal. American Journal of Epidemiology, 143 (10), p. 1035-1041. ISSN 0002-9262.

Titre du document
No long-term excess mortality after measles infection : a community study from Senegal
Année de publication
1996
Type de document
Article
Auteurs
Aaby Peter, Samb Badara, Andersen M., Simondon François
Source
American Journal of Epidemiology, 1996, 143 (10), p. 1035-1041 ISSN 0002-9262
Because measles immunization has been found in all studies to reduce mortality with more than the share of deaths attributed to acute measles, the authors examined mortality after measles infection in a study in a rural area of Senegal that included 6924 unimmunized children, of whom 1118 developped measles. Age-adjusted post-measles mortality was similar to the mortality of unvaccinated, uninfected children (mortality ratio (MR) = 1.04, 95% confidence interval (CI) 0.80-1.35). When controlling for source of infection, mortality rate was significantly different for children who contracted measles from a person outside the home (index cases vs. unvaccinated, uninfected MR = 0.27 95% CI 0.009-0.85) and for children infected at home (secondary cases vs. unvaccinated, uninfected MR = 1.10 95% CI 0.80-1.51). Hence, secondary cases had markedly higher long-term mortality than did index cases (MR = 4.13 95% CI 1.26-13.58). These estimates were essentially unchanged when the effects of season, period, separation from mother, size of community, and size of compound were investigated using a multivariate Cox regression model. The authors conclude that measles infection was not associated with increased mortality after the acute phase of infection and that index cases had lower mortality than uninfected, unvaccinated children. The reduction in mortality after measles immunization can therefore not be explained by the prevention of post-measles mortality.
Plan de classement
Divers [050DIVSAN]
Descripteurs
ROUGEOLE ; VACCINATION ; EPIDEMIOLOGIE ; MORTALITE ; ENFANT ; MILIEU RURAL ; ANALYSE MULTIVARIABLE
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010006207] ; Dakar ; Montpellier (Centre IRD)
Identifiant IRD
fdi:010006207
Contact