@article{PAR00017475,
  title = {{T}reatment outcomes and tolerability of the revised {WHO} anti-tuberculosis drug dosages for children},
  author = {{N}ansumba, {M}. and {K}umbakumba, {E}. and {O}rikiriza, {P}. and {B}astard, {M}. and {M}wanga, {J}. {A}. and {B}oum, {Y}. and {B}eaudrap, {P}ierre de and {B}onnet, {M}aryline},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {I}n 2010, the {W}orld {H}ealth {O}rganization ({WHO}) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazinamide to 35 mg/kg. {W}e assessed treatment outcomes, safety and adherence among children treated with the new recommended dosages. {METHODS} : {P}rospective cohort of children started on anti-tuberculosis treatment in {U}ganda with 12 months of follow-up, including alanine aminotransferase ({ALT}) monitoring. {T}reatment intake was observed. {RESULTS} : {O}f 144 treated children, 81 were male (56.3%), 106 (73.6%) were aged,5 years, 30 (22%) had moderate to severe malnutrition and 48 (33.3%) had human immunodeficiency virus infection. {T}reatment outcomes were as follows: 117 (81.3%) successes, 3 (2.1%) failures, 4 (2.8%) lost to follow-up, 19 (13.2%) deaths and 1 (0.7%) transferred out. {T}here was no relapse. {S}evere malnutrition (adjusted hazard ratio 8.76, 95% confidence interval [{CI}] 1.59-48.25) was the only predictor of death. {T}wo serious adverse events were attributed to treatment: one case of increased {ALT} and one with peripheral neuropathy. {M}edian {ALT} values at baseline and at weeks 2, 4 and 8 were respectively 24 (interquartile range [{IQR}] 16-39), 26 ({IQR} 18-38), 28 ({IQR} 21-40) and 27 ({IQR} 19-38) international units/l. {T}reatment adherence was above 85% on all visits. {CONCLUSION}: {W}e confirm the good tolerability of and adherence to the new treatment recommendations. {T}he increased risk of fatal outcome among severely malnourished children requires attention.},
  keywords = {tuberculosis ; treatment ; children ; mortality ; {OUGANDA}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {T}uberculosis and {L}ung {D}isease},
  volume = {22},
  numero = {2},
  pages = {151--157},
  ISSN = {1027-3719},
  year = {2018},
  DOI = {10.5588/ijtld.17.0535},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00017475},
}