%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bel Lassen, P.
%A Charlotte, F.
%A Liu, Y.
%A Bedossa, P.
%A Le Naour, G.
%A Tordjman, J.
%A Poitou, C.
%A Bouillot, J. L.
%A Genser, L.
%A Zucker, Jean-Daniel
%A Sokolovska, N.
%A Aron-Wisnewsky, J.
%A Clement, K.
%T The FAT score, a fibrosis score of adipose tissue : predicting weight-loss outcome after gastric bypass
%D 2017
%L PAR00016351
%G ENG
%J Journal of Clinical Endocrinology and Metabolism
%@ 0021-972X
%M ISI:000405621600038
%N 7
%P 2443-2453
%R 10.1210/jc.2017-00138
%U https://www.documentation.ird.fr/hor/PAR00016351
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-06/010084988.pdf
%V 102
%W Horizon (IRD)
%X Context: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. Objective: To create a semiquantitative score evaluating scAT fibrosis and test its predictive value on weight-loss response after Roux-en-Y gastric bypass (RYGB). Methods: We created a fibrosis score of adipose tissue (FAT score) integrating perilobular and pericellular fibrosis. Using this score, we characterized 183 perioperative scAT biopsy specimens from severely obese patients who underwent RYGB (n = 85 from a training cohort; n = 98 from a confirmation cohort). PR to RYGB was defined as <28% of total weight loss at 1 year (lowest tertile). The link between FAT score and PR was tested in univariate and multivariate models. Results: FAT score was directly associated with increasing scAT fibrosis measured by a standard quantification method (P for trend <0.001). FAT score interobserver agreement was good (kappa = 0.76). FAT score >= 2 was significantly associated with PR. The association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6; 95% confidence interval, 1.8 to 7.2; P = 0.003). Conclusions: The FAT score is a new, simple, semiquantitative evaluation of human scAT fibrosis that may help identify patients with a potential limited weight-loss response to RYGB.
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