@article{PAR00016351,
  title = {{T}he {FAT} score, a fibrosis score of adipose tissue : predicting weight-loss outcome after gastric bypass},
  author = {{B}el {L}assen, {P}. and {C}harlotte, {F}. and {L}iu, {Y}. and {B}edossa, {P}. and {L}e {N}aour, {G}. and {T}ordjman, {J}. and {P}oitou, {C}. and {B}ouillot, {J}. {L}. and {G}enser, {L}. and {Z}ucker, {J}ean-{D}aniel and {S}okolovska, {N}. and {A}ron-{W}isnewsky, {J}. and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontext: {B}ariatric surgery ({BS}) induces major and sustainable weight loss in many patients. {F}actors predicting poor weight-loss response ({PR}) need to be identified to improve patient care. {Q}uantification of subcutaneous adipose tissue (sc{AT}) fibrosis is negatively associated with post-{BS} weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. {O}bjective: {T}o create a semiquantitative score evaluating sc{AT} fibrosis and test its predictive value on weight-loss response after {R}oux-en-{Y} gastric bypass ({RYGB}). {M}ethods: {W}e created a fibrosis score of adipose tissue ({FAT} score) integrating perilobular and pericellular fibrosis. {U}sing this score, we characterized 183 perioperative sc{AT} biopsy specimens from severely obese patients who underwent {RYGB} (n = 85 from a training cohort; n = 98 from a confirmation cohort). {PR} to {RYGB} was defined as <28% of total weight loss at 1 year (lowest tertile). {T}he link between {FAT} score and {PR} was tested in univariate and multivariate models. {R}esults: {FAT} score was directly associated with increasing sc{AT} fibrosis measured by a standard quantification method ({P} for trend <0.001). {FAT} score interobserver agreement was good (kappa = 0.76). {FAT} score >= 2 was significantly associated with {PR}. {T}he association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6; 95% confidence interval, 1.8 to 7.2; {P} = 0.003). {C}onclusions: {T}he {FAT} score is a new, simple, semiquantitative evaluation of human sc{AT} fibrosis that may help identify patients with a potential limited weight-loss response to {RYGB}.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {C}linical {E}ndocrinology and {M}etabolism},
  volume = {102},
  numero = {7},
  pages = {2443--2453},
  ISSN = {0021-972{X}},
  year = {2017},
  DOI = {10.1210/jc.2017-00138},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00016351},
}