%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Galy, A.
%A Ciaffi, L.
%A Le Moing, V.
%A Eymard-Duvernay, Sabrina
%A Abessolo, H.
%A Toby, R.
%A Ayangma, L.
%A Le Gac, S.
%A Mpoudi-Etame, M.
%A Koulla-Shiro, S.
%A Delaporte, Eric
%A Cournil, Amandine
%T Incidence of infectious morbidity events after second-line antiretroviral therapy initiation in HIV-infected adults in Yaoundé, Cameroon
%D 2016
%L PAR00015855
%G ENG
%J Antiviral Therapy
%@ 1359-6535
%K CAMEROUN ; YAOUNDE
%M ISI:000396089600010
%N 6
%P 547-552
%R 10.3851/imp3030
%U https://www.documentation.ird.fr/hor/PAR00015855
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-03/010081630.pdf
%V 21
%W Horizon (IRD)
%X Background: Since antiretroviral therapy (ART), HIV-infected individuals experience mainly non-AIDS-related conditions, among which infectious events are prominent. We aimed to estimate incidence and describe overall spectrum of infectious events, including all grade events, among HIV-1-infected adults failing first-line ART in Yaounde, Cameroon. Methods: All patients from Cameroon enrolled in the second-line ART 2LADY trial (ANRS12169) were included in this secondary analysis. Medical files were reviewed with predefined criteria for diagnosis assessment. Incidence rates (IR) were estimated per 100 person-years (% PY). Results: A total of 302 adult patients contributing 840 PY experienced 596 infectious events (IR 71% PY). Only 29 (5%) events were graded as severe. Most frequent infections were upper respiratory tract infections (15% PY), diarrhoea (9% PY) and malaria (9% PY). A total of 369 (62%) infections occurred during the first year (IR 130% PY) followed by a persistent lower incidence during the following 3 years. Higher IR were observed in patients with CD4(+) T-cell count < 200 cells/mm(3) for all infectious events except for mycobacterial and parasitic infections. IR of viral, bacterial and parasitic infectious events were lower in case of co-trimoxazole use in patients with CD4(+) T-cell count < 200 cells/mm(3). Conclusions: Infectious events are common and mainly occur during the first year after treatment initiation. Second-line ART initiation had a positive impact on the entire spectrum of infectious morbidity.
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