@article{PAR00015855,
  title = {{I}ncidence of infectious morbidity events after second-line antiretroviral therapy initiation in {HIV}-infected adults in {Y}aound{\'e}, {C}ameroon},
  author = {{G}aly, {A}. and {C}iaffi, {L}. and {L}e {M}oing, {V}. and {E}ymard-{D}uvernay, {S}abrina and {A}bessolo, {H}. and {T}oby, {R}. and {A}yangma, {L}. and {L}e {G}ac, {S}. and {M}poudi-{E}tame, {M}. and {K}oulla-{S}hiro, {S}. and {D}elaporte, {E}ric and {C}ournil, {A}mandine},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}ince antiretroviral therapy ({ART}), {HIV}-infected individuals experience mainly non-{AIDS}-related conditions, among which infectious events are prominent. {W}e aimed to estimate incidence and describe overall spectrum of infectious events, including all grade events, among {HIV}-1-infected adults failing first-line {ART} in {Y}aounde, {C}ameroon. {M}ethods: {A}ll patients from {C}ameroon enrolled in the second-line {ART} 2{LADY} trial ({ANRS}12169) were included in this secondary analysis. {M}edical files were reviewed with predefined criteria for diagnosis assessment. {I}ncidence rates ({IR}) were estimated per 100 person-years (% {PY}). {R}esults: {A} total of 302 adult patients contributing 840 {PY} experienced 596 infectious events ({IR} 71% {PY}). {O}nly 29 (5%) events were graded as severe. {M}ost frequent infections were upper respiratory tract infections (15% {PY}), diarrhoea (9% {PY}) and malaria (9% {PY}). {A} total of 369 (62%) infections occurred during the first year ({IR} 130% {PY}) followed by a persistent lower incidence during the following 3 years. {H}igher {IR} were observed in patients with {CD}4(+) {T}-cell count < 200 cells/mm(3) for all infectious events except for mycobacterial and parasitic infections. {IR} of viral, bacterial and parasitic infectious events were lower in case of co-trimoxazole use in patients with {CD}4(+) {T}-cell count < 200 cells/mm(3). {C}onclusions: {I}nfectious events are common and mainly occur during the first year after treatment initiation. {S}econd-line {ART} initiation had a positive impact on the entire spectrum of infectious morbidity.},
  keywords = {{CAMEROUN} ; {YAOUNDE}},
  booktitle = {},
  journal = {{A}ntiviral {T}herapy},
  volume = {21},
  numero = {6},
  pages = {547--552},
  ISSN = {1359-6535},
  year = {2016},
  DOI = {10.3851/imp3030},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015855},
}