%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Klitting, R.
%A Gould, E. A.
%A Lamballerie, Xavier de
%T G plus C content differs in conserved and variable amino acid residues of flaviviruses and other evolutionary groups
%D 2016
%L PAR00015362
%G ENG
%J Infection Genetics and Evolution
%@ 1567-1348
%K Flavivirus ; Evolution ; G plus C content
%M ISI:000388574400044
%P 332-340
%R 10.1016/j.meegid.2016.09.017
%U https://www.documentation.ird.fr/hor/PAR00015362
%V 45
%W Horizon (IRD)
%X Flaviviruses are small RNA viruses that exhibit genetic and ecological diversity and awide range of G + C content (GC%). We discovered that, amongst flaviviruses, the GC% of nucleotides encoding conserved amino acid (AA) residues was consistently higher than that of nucleotides encoding variable AAs. This intriguing phenomenon was also identified for a wide range of other viruses, and some non-viral evolutionary groups. Here, we analyse the possible mechanisms underlying this imbalanced nucleotide content (in particular the role of the specific G content and the AA composition in flaviviral genomes) and discuss its evolutionary implications. Our findings suggest that one of the most simple characteristics of the genetic code (i.e., the G or G + C content of codons) is linked with the evolutionary behavior of the corresponding encoded AAs.
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