@article{PAR00015362,
  title = {{G} plus {C} content differs in conserved and variable amino acid residues of flaviviruses and other evolutionary groups},
  author = {{K}litting, {R}. and {G}ould, {E}. {A}. and {L}amballerie, {X}avier de},
  editor = {},
  language = {{ENG}},
  abstract = {{F}laviviruses are small {RNA} viruses that exhibit genetic and ecological diversity and awide range of {G} + {C} content ({GC}%). {W}e discovered that, amongst flaviviruses, the {GC}% of nucleotides encoding conserved amino acid ({AA}) residues was consistently higher than that of nucleotides encoding variable {AA}s. {T}his intriguing phenomenon was also identified for a wide range of other viruses, and some non-viral evolutionary groups. {H}ere, we analyse the possible mechanisms underlying this imbalanced nucleotide content (in particular the role of the specific {G} content and the {AA} composition in flaviviral genomes) and discuss its evolutionary implications. {O}ur findings suggest that one of the most simple characteristics of the genetic code (i.e., the {G} or {G} + {C} content of codons) is linked with the evolutionary behavior of the corresponding encoded {AA}s.},
  keywords = {{F}lavivirus ; {E}volution ; {G} plus {C} content},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {45},
  numero = {},
  pages = {332--340},
  ISSN = {1567-1348},
  year = {2016},
  DOI = {10.1016/j.meegid.2016.09.017},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015362},
}