@article{PAR00015233,
  title = {{A} regional outbreak of {C}lostridium difficile {PCR}-ribotype 027 infections in {S}outheastern {F}rance from a single long-term {C}are facility},
  author = {{C}assir, {N}. and {D}elaroziere, {J}. {C}. and {D}ubourg, {G}. and {D}elord, {M}. and {L}agier, {J}. {C}. and {B}rouqui, {P}. and {F}enollar, {F}. and {R}aoult, {D}idier and {F}ournier, {P}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVE}. {T}o describe and analyze a large outbreak of {C}lostridium difficile 027 ({CD}-027) infections. {METHODS}. {C}onfirmed {CD}-027 cases were defined as {CD} infection plus real-time polymerase chain reaction assay ({PCR}) positive for {CD}-027. {C}linical and microbiological data on patients with {CD}-027 infection were collected from {J}anuary 2013 to {D}ecember 2015 in the {P}rovence-{A}lpes-{C}ote-d'{A}zur region (southeastern {F}rance). {RESULTS}. {I}n total, 19 healthcare facilities reported 144 {CD}-027 infections (112 confirmed and 32 probable {CD}-027 infections) during a 22-month period outbreak. {A}lthough the incidence rate per 10,000 bed days was lower in long-term care facilities ({LTCF}s) than in acute care facilities (0.05 vs 0.14; {P} < .001), cases occurred mainly in {LTCF}s, one of which was the probable source of this outbreak. {A}fter centralization of {CD} testing, the rate of confirmed {CD}-027 cases from {LTCF}s or residential-care homes increased significantly (69% vs 92%; {P} < .001). {R}egarding confirmed {CD}-027 patients, the sex ratio and the median age were 0.53 and 84.2 years, respectively. {T}he 30-day crude mortality rate was 31%. {M}ost patients (96%) had received antibiotics within 3 months prior to the {CD} colitis diagnosis. {D}uring the study period, the rate of patients with {CD}-027 (compared with all patients tested in the point-of-care laboratories) decreased significantly ({P} = .03). {CONCLUSIONS}. {A} large {CD}-027 outbreak occurred in southeastern {F}rance as a consequence of an initial cluster of cases in a single {LTCF}. {S}uccessful interventions included rapid isolation and testing of residents with potentially infectious diarrhea and cohorting of case patients in a specialized infectious diseases ward to optimize management.},
  keywords = {},
  booktitle = {},
  journal = {{I}nfection {C}ontrol and {H}ospital {E}pidemiology},
  volume = {37},
  numero = {11},
  pages = {1337--1341},
  ISSN = {0899-823{X}},
  year = {2016},
  DOI = {10.1017/ice.2016.164},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015233},
}