@article{PAR00015221,
  title = {{G}ender-specific associations of genetic variants with metabolic syndrome components in the {T}unisian population},
  author = {{E}louej, {S}. and {R}ejeb, {I}. and {A}ttaoua, {R}. and {N}agara, {M}. and {S}allem, {O}. {K}. and {K}amoun, {I}. and {C}hargui, {M}. and {J}amoussi, {H}. and {T}urki, {Z}. and {A}bid, {A}. and {B}en {S}lama, {C}. and {B}ahri, {S}. and {B}en {R}omdhane, {H}. and {A}bdelhak, {S}. and {K}efi, {R}. and {G}rigorescu, {F}lorin},
  editor = {},
  language = {{ENG}},
  abstract = {{A}im of the study: {R}ecent genome-wide association studies ({GWAS}s) have identified many genetic variants associated with metabolic syndrome ({M}et{S}). {H}owever, their contribution to {M}et{S} in ethnic groups in {T}unisia is largely unexplored. {I}n this study, we aim to examine the associations of related loci with a risk of metabolic syndrome in a sample of {T}unisians. {M}aterials and methods: {O}verall seven polymorphisms rs7265718, rs10401969, rs762861, rs12310367, rs1562398, rs2059807, rs4420638 located at {C}20orf152, {CILP}2, {LRPAP}1, {ZNF}664, {KLF}14, {INSR}, {APOE}, respectively, were analyzed in 356 samples from the {T}unisian population. {A}nthropometric and biochemical parameters were assessed. {M}etabolic syndrome was defined according to the {I}nternational {D}iabetes {F}ederation ({IDF}). {R}esults: {W}e find that {LRPAP}1-rs762861 {C} allele increases susceptibility to {M}et{S} ({OR} = 1.39, 95% {CI} = 0.99-1.95, p = 0.041). {S}eparate analysis in men and women revealed the association of rs762861 among females ({OR} = 1.6, 95% {CI} = 1.057-2.41, p = 0.021), but not among males ({OR} = 0.953, 95% {CI} = 0.51-1.78, p = 0.882). {ZNF}664-rs12310367 was also found to be associated with body mass index ({BMI}) in women (p = 0.01) and not in men (p = 0.18). {KLF}14-rs1562398 was significantly correlated with impaired fasting glucose (p = 0.004) only in men. {C}onclusions: {O}ur results reveal new candidate genes for {M}et{S} in the {T}unisian population and suggest that the genetic basis of this syndrome is gender dependent. {F}urther studies are necessary to understand why these associations differ between males and females.},
  keywords = {{G}ender ; metabolic syndrome ; {N}orth {A}frica ; polymorphisms ; {T}unisia ; {TUNISIE}},
  booktitle = {},
  journal = {{E}ndocrine {R}esearch},
  volume = {41},
  numero = {4},
  pages = {300--309},
  ISSN = {0743-5800},
  year = {2016},
  DOI = {10.3109/07435800.2016.1141945},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015221},
}