@article{PAR00015082,
  title = {{F}-18-{FDG} {PET}/{CT} as a central tool in the shift from chronic {Q} fever to {C}oxiella burnetii persistent focalized infection : a consecutive case series},
  author = {{E}ldin, {C}. and {M}elenotte, {C}. and {M}illion, {M}. and {C}ammilleri, {S}. and {S}otto, {A}. and {E}lsendoorn, {A}. and {T}huny, {F}. and {L}epidi, {H}. and {R}oblot, {F}. and {W}eitten, {T}. and {A}ssaad, {S}. and {B}ouaziz, {A}. and {C}hapuzet, {C}. and {G}ras, {G}. and {L}abussiere, {A}. {S}. and {L}andais, {C}. and {L}onguet, {P}. and {M}asseau, {A}. and {M}undler, {O}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ecause {Q} fever is mostly diagnosed serologically, localizing a persistent focus of {C}oxiella burnetii infection can be challenging. {F}-18-fluorodeoxyglucose positron emission tomography/computed tomography ({F}-18-{FDG} {PET}/{CT}) could be an interesting tool in this context.{W}e performed a retrospective study on patients diagnosed with {C} burnetii infection, who had undergone {F}-18-{FDG} {PET}/{CT} between 2009 and 2015. {W}hen positive {F}-18-{FDG} {PET}/{CT} results were obtained, we tried to determine if it changed the previous diagnosis by discovering or confirming a suspected focus of {C} burnetii infection.{O}ne hundred sixty-seven patients benefited from {F}-18-{FDG} {PET}/{CT}. {T}he most frequent clinical subgroup before {F}-18-{FDG} {PET}/{CT} was patients with no identified focus of infection, despite high {I}g{G}1 serological titers (34%). {F}or 59% (n=99) of patients, a hypermetabolic focus was identified. {F}or 62 patients (62.6%), the positive {F}-18-{FDG} {PET}/{CT} allowed the diagnosis to be changed. {F}or 24 of them, (38.7%), a previously unsuspected focus of infection was discovered. {F}orty-two (42%) positive patients had more than 1 hypermetabolic focus. {W}e observed 21 valvular foci, 34 vascular foci, and a high proportion of osteoarticular localizations (n=21). {W}e also observed lymphadenitis (n=27), bone marrow hypermetabolism (n=11), and 9 pulmonary localizations.{W}e confirmed that(18){F}-{FDG} {PET}/{CT} is a central tool in the diagnosis of {C} burnetii focalized persistent infection. {W}e proposed new diagnostic scores for 2 main clinical entities identified using {F}-18-{FDG} {PET}/{CT}: osteoarticular persistent infections and lymphadenitis.},
  keywords = {{F}-18-{FDG} {PET} ; {CT} ; {C}oxiella burnetii ; diagnosis ; focalized persistent ; infection ; {Q} fever ; {FRANCE}},
  booktitle = {},
  journal = {{M}edicine},
  volume = {95},
  numero = {34},
  pages = {e4287},
  ISSN = {0025-7974},
  year = {2016},
  DOI = {10.1097/md.0000000000004287},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015082},
}