Eldin C., Melenotte C., Million M., Cammilleri S., Sotto A., Elsendoorn A., Thuny F., Lepidi H., Roblot F., Weitten T., Assaad S., Bouaziz A., Chapuzet C., Gras G., Labussiere A. S., Landais C., Longuet P., Masseau A., Mundler O., Raoult Didier. (2016). F-18-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection : a consecutive case series. Medicine, 95 (34), p. e4287. ISSN 0025-7974.
Titre du document
F-18-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection : a consecutive case series
Année de publication
2016
Auteurs
Eldin C., Melenotte C., Million M., Cammilleri S., Sotto A., Elsendoorn A., Thuny F., Lepidi H., Roblot F., Weitten T., Assaad S., Bouaziz A., Chapuzet C., Gras G., Labussiere A. S., Landais C., Longuet P., Masseau A., Mundler O., Raoult Didier
Source
Medicine, 2016,
95 (34), p. e4287 ISSN 0025-7974
Because Q fever is mostly diagnosed serologically, localizing a persistent focus of Coxiella burnetii infection can be challenging. F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) could be an interesting tool in this context.We performed a retrospective study on patients diagnosed with C burnetii infection, who had undergone F-18-FDG PET/CT between 2009 and 2015. When positive F-18-FDG PET/CT results were obtained, we tried to determine if it changed the previous diagnosis by discovering or confirming a suspected focus of C burnetii infection.One hundred sixty-seven patients benefited from F-18-FDG PET/CT. The most frequent clinical subgroup before F-18-FDG PET/CT was patients with no identified focus of infection, despite high IgG1 serological titers (34%). For 59% (n=99) of patients, a hypermetabolic focus was identified. For 62 patients (62.6%), the positive F-18-FDG PET/CT allowed the diagnosis to be changed. For 24 of them, (38.7%), a previously unsuspected focus of infection was discovered. Forty-two (42%) positive patients had more than 1 hypermetabolic focus. We observed 21 valvular foci, 34 vascular foci, and a high proportion of osteoarticular localizations (n=21). We also observed lymphadenitis (n=27), bone marrow hypermetabolism (n=11), and 9 pulmonary localizations.We confirmed that(18)F-FDG PET/CT is a central tool in the diagnosis of C burnetii focalized persistent infection. We proposed new diagnostic scores for 2 main clinical entities identified using F-18-FDG PET/CT: osteoarticular persistent infections and lymphadenitis.
Plan de classement
Santé : généralités [050]
;
Biotechnologies [084]
Description Géographique
FRANCE
Identifiant IRD
PAR00015082
