@article{PAR00015074,
  title = {{T}hree nuclear and two membrane estrogen receptors in basal teleosts, {A}nguilla sp. : identification, evolutionary history and differential expression regulation},
  author = {{L}afont, {A}. {G}. and {R}ousseau, {K}. and {T}omkiewicz, {J}. and {D}ufour, {S}ylvie},
  editor = {},
  language = {{ENG}},
  abstract = {{E}strogens interact with classical intracellular nuclear receptors ({ESR}), and with {G}-coupled membrane receptors ({GPER}). {I}n the eel, we identified three nuclear ({ESR}1, {ESR}2a, {ESR}2b) and two membrane ({GPER}a, {GPER}b) estrogen receptors. {D}uplicated {ESR}2 and {GPER} were also retrieved in most extant teleosts. {P}hylogeny and synteny analyses suggest that they result from teleost whole genome duplication (3{R}). {I}n contrast to conserved 3{R}-duplicated {ESR}2 and {GPER}, one of 3{R}-duplicated {ESR}1 has been lost shortly after teleost emergence. {Q}uantitative {PCR}s revealed that the five receptors are all widely expressed in the eel, but with differential patterns of tissue expression and regulation. {ESR}1 only is consistently up-regulated in vivo in female eel {BPG}-liver axis during induced sexual maturation, and also up regulated in vitro by estradiol in eel hepatocyte primary cultures. {T}his first comparative study of the five teleost estradiol receptors provides bases for future investigations on differential roles that may have contributed to the conservation of multiple estrogen receptors.},
  keywords = {{E}strogen nuclear receptor ; {E}strogen membrane receptor ; {T}eleosts ; {E}volution ; {H}epatocytes ; {E}el},
  booktitle = {},
  journal = {{G}eneral and {C}omparative {E}ndocrinology},
  volume = {235},
  numero = {},
  pages = {177--191},
  ISSN = {0016-6480},
  year = {2016},
  DOI = {10.1016/j.ygcen.2015.11.021},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00015074},
}