Publications des scientifiques de l'IRD

Madelain V., Nguyen T. H. T., Olivo A., de Lamballerie Xavier, Guedj J., Taburet A. M., Mentre F. (2016). Ebola virus infection : review of the pharmacokinetic and pharmacodynamic properties of drugs considered for testing in human efficacy trials. Clinical Pharmacokinetics, 55 (8), p. 907-923. ISSN 0312-5963.

Titre du document
Ebola virus infection : review of the pharmacokinetic and pharmacodynamic properties of drugs considered for testing in human efficacy trials
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000379483600002
Auteurs
Madelain V., Nguyen T. H. T., Olivo A., de Lamballerie Xavier, Guedj J., Taburet A. M., Mentre F.
Source
Clinical Pharmacokinetics, 2016, 55 (8), p. 907-923 ISSN 0312-5963
The 2014-2015 outbreak of Ebola virus disease is the largest epidemic to date in terms of the number of cases, deaths, and affected areas. In October 2015, no antiviral agents had proven antiviral efficacy in patients. However, in September 2014, the World Health Organization inventoried and has since regularly updated a list of potential drug candidates with demonstrated antiviral efficacy in in vitro or animal models. This includes agents belonging to various therapeutic classes, namely direct antiviral agents (favipiravir and BCX4430), a combination of antibodies (ZMapp), type I interferons, RNA interference-based drugs (TKM-Ebola and AVI-7537), and anticoagulant drugs (rNAPc2). Here, we review the pharmacokinetic and pharmacodynamic information presently available for these drugs, using data obtained in healthy volunteers for pharmacokinetics and data obtained in human clinical trials or animal models for pharmacodynamics. Future studies evaluating these drugs in clinical trials are critical to confirm their efficacy in humans, propose appropriate doses, and evaluate the possibility of treatment combinations.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE DE L'OUEST
Localisation
Fonds IRD
Identifiant IRD
PAR00014891
Contact