@article{PAR00014809,
  title = {{U}nifying view of stem-loop hairpin {RNA} as origin of current and ancient parasitic and non-parasitic {RNA}s, including in giant viruses},
  author = {{S}eligmann, {H}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{P}utatively, stem-loop {RNA} hairpins explain networks of selfish elements and {RNA} world remnants. {T}heir genomic density increases with intracellular lifestyle, especially when comparing giant viruses and their virophages. {RNA} protogenomes presumably templated for m{RNA}s and self replicating stem-loops, ancestors of modern genes and parasitic sequences, including t{RNA}s and r{RNA}s. {P}rimary and secondary structure analyses suggest common ancestry for t/r{RNA}s and parasitic {RNA}s, parsimoniously link diverse {RNA} metabolites (replication origins, t{RNA}s, ribozymes, riboswitches, mi{RNA}s and r{RNA}s) to parasitic {RNA}s (ribosomal viroids, {R}ickettsia repeated palindromic elements ({RPE}), stem-loop hairpins in giant viruses, their virophages, and transposable retrovirus-derived elements). {R}esults indicate ongoing genesis of small {RNA} metabolites, and common ancestry or similar genesis for r{RNA} and retroviral sequences. {A}ssuming functional integration of modular duplicated {RNA} hairpins evolutionarily unifies diverse molecules, postulating stem-loop hairpin {RNA}s as origins of genetic innovation, ancestors of r{RNA}s, retro- and {M}imivirus sequences, and cells.},
  keywords = {},
  booktitle = {},
  journal = {{C}urrent {O}pinion in {M}icrobiology},
  volume = {31},
  numero = {},
  pages = {1--8},
  ISSN = {1369-5274},
  year = {2016},
  DOI = {10.1016/j.mib.2015.11.004},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014809},
}