@article{PAR00014700,
  title = {{D}ecreasing level of resistance in invasive {K}lebsiella pneumoniae strains isolated in {M}arseille, {J}anuary 2012-{J}uly 2015},
  author = {{A}bat, {C}. and {R}aoult, {D}idier and {R}olain, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {K}lebsiella pneumoniae is a {G}ram-negative bacterial species well known for its capacity to cause infections in humans, and to carry and spread a wide variety of resistance genes including extended-spectrum beta-lactamase genes, carbapenem resistance genes, and colistin resistance genes. {R}ecently, our real-time laboratory-based surveillance system {MARSS} (the {M}arseille {A}ntibiotic {R}esistance {S}urveillance {S}ystem) allowed us to observe a intringing dramatic decrease in the beta-lactam resistance level of the {K}. pneumoniae strains routinely isolated from patients hospitalized in our settings since 2013. {H}ere we study the evolution of the prevalence of {K}. pneumoniae infections in {M}arseille university hospitals, {F}rance, from {J}anuary 2012 to {J}uly 2015, and study their antibiotic resistance profiles. {M}ethods: {W}e collected data referring to patients hostpitalized for {K}. pneumoniae infections in the 4 university hospitals of {M}arseille from {J}anuary 2012 to {J}uly 2015. {W}e then study their antibiotic resistance profiles according the clinical sites from which each strain was collected. {A}ntibiotic consumption data from our four hospitals were also analyzed from {J}anuary 2013 to {J}uly 2015. {R}esults: {O}verall, 4868 patients were admitted in our settings for {K}. pneumoniae infections over the study period. {O}verall, 40.1, 22.3, 25.6, 0.4, 29.9, 14.8, 27.3 and 37.0 % of the strains were resistant to amoxicillin plus clavulanic acid, piperacillin-tazobactam, ceftriaxone, imipenem, ciprofloxacin, gentamicin, trimethoprim-sulfamethoxazole and furan, respectively. 447 were invasive infections. {T}he resistance level of our invasive strains was significantly lower than that presented by 11, 7, 10 and 11 other {E}uropean countries included in the 2013 {E}uropean {A}ntimicrobial {R}esistance {S}urveillance {N}etwork report for ceftriaxone, imipenem, ciprofloxacin and gentamicin, respectively, but significantly higher than that of 13, 1, 17 and 13 {E}uropean countries for the same antibiotics. {W}e also observed that the percentages of resistance of our invasive strains to three of the four antibiotics decreased over the study. {I}n parallel, antibiotic consumption remained stable in our four hospitals from {J}anuary 2013 to {J}uly 2015. {C}onclusions: {A}ltogether, our results underline that automated antibiotic-susceptibility testing results-based surveillance systems are crucial to better understand the evolving epidemiology of dangerous pathogenic bacterial species, like {K}. pneumoniae, at local scales.},
  keywords = {{H}istorical database ; {K}. pneumoniae ; {L}aboratory-based surveillance ; system ; {C}arbapenem ; {FRANCE}},
  booktitle = {},
  journal = {{S}pringerplus},
  volume = {5},
  numero = {},
  pages = {art. 631},
  ISSN = {2193-1801},
  year = {2016},
  DOI = {10.1186/s40064-016-2296-0},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014700},
}