@article{PAR00014698,
  title = {{N}ovel 2-phenyl-5-[({E})-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[({E})-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting {NS}5 polymerase},
  author = {{B}enmansour, {F}. and {E}ydoux, {C}. and {Q}uerat, {G}. and de {L}amballerie, {X}avier and {C}anard, {B}. and {A}lvarez, {K}. and {G}uillemot, {J}. {C}. and {B}arral, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}sing a functional high-throughput screening ({HTS}) and subsequent {SAR} studies, we have discovered a novel series of non-nucleoside dengue viral polymerase inhibitors. {W}e report the elaboration of {SAR} around hit compound 1 as well as the synthesis and antiviral evaluation of 3-phenyl-5-[({E})-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole and 5-phenyl-2-[2-(2-thienyl)ethenyl]-1,3,4-oxadiazole analogues derived from a rapid and easily accessible chemical pathway. {A} large number of compounds prepared by this method were shown to possess in vitro activity against the polymerase of dengue virus. {T}he most potent inhibitors were tested against {D}engue virus clinical isolates on infected cells model and exhibit submicromolar activity on the four dengue virus serotypes.},
  keywords = {2-phenyl-5-[({E})-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole ; 3-phenyl-5-[({E})-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole ; {D}engue ; virus ; {NS}5 {R}d{R}p inhibitors ; {A}ntiviral activity},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {M}edicinal {C}hemistry},
  volume = {109},
  numero = {},
  pages = {146--156},
  ISSN = {0223-5234},
  year = {2016},
  DOI = {10.1016/j.ejmech.2015.12.046},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014698},
}