@article{PAR00014691,
  title = {{D}o we need new antibiotics ?},
  author = {{R}olain, {J}. {M}. and {A}bat, {C}. and {J}imeno, {M}. {T}. and {F}ournier, {P}. {E}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{F}or several years, alarmist articles both in mass media and in the scientific community have reported an increase in antibiotic resistance, even citing an inability to treat patients infected with multidrug-resistant bacteria ({MDR}) responsible for high mortality worldwide. {I}n this review we summarize and discuss the key points associated with the reality of (i) the existence of pandrug-resistant bacteria, (ii) the increase of resistance worldwide, (iii) the link between resistance and death, and (iv) the need to develop new antibiotics. {D}ata on antibiotic resistance in {E}urope for the main bacteria associated with invasive infections apparently demonstrate that apart from {K}lebsiella pneumoniae, which is resistant to carbapenems in three countries ({R}omania, {I}taly and {G}reece), the level of resistance to three or more classes of antibiotics (defined as {MDR} phenotype) has remained low and stable over the last 5 years and that therapeutic options exist both for reference antibiotics and for old antibiotics. {T}he clinical outcome of patients infected by {MDR} bacteria remains controversial and death rates attributable to {MDR} bacteria versus non-{MDR} bacteria are still debated. {T}he arsenal of antibiotics currently available (including 'old antibiotics') suffices for facing the waves of emergence of new bacterial resistance and should be considered as a {W}orld {H}eritage. {T}his heritage should be managed in a non-profit model with international regulatory approval.},
  keywords = {{A}ntimicrobial resistance ; old antibiotics},
  booktitle = {},
  journal = {{C}linical {M}icrobiology and {I}nfection},
  volume = {22},
  numero = {5},
  pages = {408--415},
  ISSN = {1198-743{X}},
  year = {2016},
  DOI = {10.1016/j.cmi.2016.03.012},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014691},
}