@article{PAR00014560,
  title = {{R}eevaluation of possible outcomes of infections with human immunodeficiency virus},
  author = {{T}amalet, {C}. and {C}olson, {P}. and {D}ecroly, {E}. and {D}hiver, {C}. and {R}avaux, {I}. and {S}tein, {A}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{S}everal lines of evidence indicate that {HIV} infection can result in several possible incomes, including a very small proportion of individuals whose {HIV} replication is controlled after treatment interruption (known as {HIV} posttreatment controllers) or spontaneously without any treatment (known as {HIV} elite controllers). {B}oth types of individuals are {HIV} {RNA} negative but {HIV} {DNA} positive, with living virus which can be stimulated ex vivo. {A} review was conducted to assess the literature on yet rarer cases with detectable integrated {HIV} {DNA} without {HIV} infectious virus in {HIV}-seropositive or -negative individuals. {T}hree categories of patients were identified: (a) {HIV}-seropositive individuals with apparent spontaneous cure from their {HIV} infection, (b) {HIV}-seronegative children born to {HIV}-infected mothers and (c) highly exposed seronegative adults. {V}alidity criteria were proposed to assess the presence of integrated {HIV} {DNA} as possible or unquestionable in these three categories. {O}nly three articles among the 22 ultimately selected fulfilled these criteria. {A}mong the highly exposed seronegative subjects, some individuals were described as being without integrated {HIV} {DNA}, probably because these subjects were not investigated using relevant, highly sensitive methods. {F}inally, we propose a definition of spontaneous cure of {HIV} infection based on clinical, immunologic and virologic criteria.},
  keywords = {{C}ure ; dead-end infection ; endogenous retrovirus ; {HIV} ; viral integration},
  booktitle = {},
  journal = {{C}linical {M}icrobiology and {I}nfection},
  volume = {22},
  numero = {4},
  pages = {299--311},
  ISSN = {1198-743{X}},
  year = {2016},
  DOI = {10.1016/j.cmi.2015.11.022},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014560},
}