@article{PAR00014442, title = {{I}solation, full genomic characterization and neutralization-based human seroprevalence of {M}edjerda {V}alley virus, a novel sandfly-borne phlebovirus belonging to the {S}alehabad virus complex in northern {T}unisia}, author = {{B}ichaud, {L}. and {D}achraoui, {K}. and {A}lwassouf, {S}. and {A}lkan, {C}. and {M}ensi, {M}. and {P}iorkowski, {G}. and {S}akhria, {S}. and {S}eston, {M}organ and {F}ares, {W}. and de {L}amballerie, {X}avier and {Z}hioua, {E}. and {C}harrel, {R}. {N}.}, editor = {}, language = {{ENG}}, abstract = {{A} new phlebovirus, {M}edjerda {V}alley virus ({MVV}), was isolated from one pool of {P}hlebotomus sp. ({D}iptera; {P}sychodidae) sandflies trapped in the vicinity of the {U}tique site, northern {T}unisia. {G}enetic analysis based on complete coding of genomic sequences of the three {RNA} segments indicated that {MVV} is most closely related to members of the {S}alehabad virus species, where it is the fourth virus for which the complete sequence is available. {A} seroprevalence study was performed to search for neutralizing antibodies in human sera in the same region. {T}he results demonstrate that in this area, {MVV} can readily infect humans despite low seroprevalence rates. {S}alehabad species viruses have generally been considered to be a group of viruses with little medical or veterinary interest. {T}his view deserves to be revisited according to our human seroprevalence results, together with high animal infection rate of {A}dana virus and recent evidence of human infection with {A}dria virus in {G}reece. {F}urther studies are needed to investigate the capacity of each specific member of the {S}alehabad virus species to cause human or animal diseases.}, keywords = {{TUNISIE}}, booktitle = {}, journal = {{J}ournal of {G}eneral {V}irology}, volume = {97}, numero = {3}, pages = {602--610}, ISSN = {0022-1317}, year = {2016}, DOI = {10.1099/jgv.0.000389}, URL = {https://www.documentation.ird.fr/hor/{PAR}00014442}, }