@article{PAR00014431,
  title = {{E}xperimental treatment with {F}avipiravir for {E}bola virus disease (the {JIKI} trial) : a historically controlled, single-arm proof-of-concept trial in {G}uinea},
  author = {{S}issoko, {D}. and {L}aouenan, {C}. and {F}olkesson, {E}. and {M}'{L}ebing, {A}. {B}. and {B}eavogui, {A}. {H}. and {B}aize, {S}. and {C}amara, {A}. {M}. and {M}aes, {P}. and {S}hepherd, {S}. and {D}anel, {C}. and {C}arazo, {S}. and {C}onde, {M}. {N}. and {G}ala, {J}. {L}. and {C}olin, {G}. and {S}avini, {H}. and {B}ore, {J}. {A}. and {L}e {M}arcis, {F}. and {K}oundouno, {F}. {R}. and {P}etitjean, {F}. and {L}amah, {M}. {C}. and {D}iederich, {S}. and {T}ounkara, {A}. and {P}oelart, {G}. and {B}erbain, {E}. and {D}indart, {J}. {M}. and {D}uraffour, {S}. and {L}efevre, {A}. and {L}eno, {T}. and {P}eyrouset, {O}. and {I}renge, {L}. and {B}angoura, {N}. and {P}alich, {R}. and {H}inzmann, {J}. and {K}raus, {A}. and {B}arry, {T}. {S}. and {B}erette, {S}. and {B}ongono, {A}. and {C}amara, {M}. {S}. and {M}unoz, {V}. {C}. and {D}oumbouya, {L}. and {H}arouna, {S}. and {K}ighoma, {P}. {M}. and {L}olamou, {R}. and {L}oua, {C}. {M}. and {M}assala, {V}. and {M}oumouni, {K}. and {P}rovost, {C}. and {S}amake, {N}. and {S}ekou, {C}. and {S}oumah, {A}. and {A}rnould, {I}. and {K}omano, {M}. {S}. and {G}ustin, {L}. and {B}erutto, {C}. and {C}amara, {D}. and {C}amara, {F}. {S}. and {C}olpaert, {J}. and {D}elamou, {L}. and {J}ansson, {L}. and {K}ourouma, {E}. and {L}oua, {M}. and {M}alme, {K}. and {M}anfrin, {E}. and {M}aomou, {A}. and {M}ilinouno, {A}. and {O}mbelet, {S}. and {S}idiboun, {A}. {Y}. and {V}erreckt, {I}. and {Y}ombouno, {P}. and {B}ocquin, {A}. and {C}arbonnelle, {C}. and {C}armoi, {T}. and {F}range, {P}. and {M}ely, {S}. and {N}guyen, {V}. {K}. and {P}annetier, {D}. and {T}aburet, {A}. {M}. and {T}reluyer, {J}. {M}. and {K}olie, {J}. and {M}oh, {R}. and {G}onzalez, {M}. {C}. and {K}uisma, {E}. and {L}iedigk, {B}. and {N}gabo, {D}. and {R}udolf, {M}. and {T}hom, {R}. and {K}erber, {R}. and {G}abriel, {M}. and {W}lfel, {R}. and {W}olfel, {R}. and {B}adir, {J}. and {B}entahir, {M}. and {D}eccache, {Y}. and {D}umont, {C}. and {D}urant, {J}. {F}. and {E}l {B}akkouri, {K}. and {U}wamahoro, {M}. {G}. and {S}mits, {B}. and {T}oufik, {N}. and {V}an {C}auwenberghe, {S}. and {E}zzedine, {K}. and {D}ortenzio, {E}. and {P}izarro, {L}. and {E}tienne, {A}. and {G}uedj, {J}. and {F}izet, {A}. and de {S}ainte {F}are, {E}. {B}. and {M}urgue, {B}. and {T}uan, {T}. {M}. and {R}app, {C}. and {P}iguet, {P}. and {P}oncin, {M}. and {D}raguez, {B}. and {D}uverger, {T}. {A}. and {B}arbe, {S}. and {B}aret, {G}. and {D}efourny, {I}. and {C}arroll, {M}. and {R}aoul, {H}. and {A}ugier, {A}. and {E}holie, {S}. {P}. and {Y}azdanpanah, {Y}. and {L}evy-{M}archal, {C}. and {A}ntierrens, {A}. and {V}an {H}erp, {M}. and {G}unther, {S}. and de {L}amballerie, {X}avier and {K}eita, {S}. and {M}entre, {F}. and {A}nglaret, {X}. and {M}alvy, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}bola virus disease ({EVD}) is a highly lethal condition for which no specific treatment has proven efficacy. {I}n {S}eptember 2014, while the {E}bola outbreak was at its peak, the {W}orld {H}ealth {O}rganization released a short list of drugs suitable for {EVD} research. {F}avipiravir, an antiviral developed for the treatment of severe influenza, was one of these. {I}n late 2014, the conditions for starting a randomized {E}bola trial were not fulfilled for two reasons. {O}ne was the perception that, given the high number of patients presenting simultaneously and the very high mortality rate of the disease, it was ethically unacceptable to allocate patients from within the same family or village to receive or not receive an experimental drug, using a randomization process impossible to understand by very sick patients. {T}he other was that, in the context of rumors and distrust of {E}bola treatment centers, using a randomized design at the outset might lead even more patients to refuse to seek care. {T}herefore, we chose to conduct a multicenter non-randomized trial, in which all patients would receive favipiravir along with standardized care. {T}he objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large {E}bola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with {EVD}. {T}he trial was not aimed at directly informing future guidelines on {E}bola treatment but at quickly gathering standardized preliminary data to optimize the design of future studies.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{P}los {M}edicine},
  volume = {13},
  numero = {3},
  pages = {e1001967 [36 p.]},
  ISSN = {1549-1676},
  year = {2016},
  DOI = {10.1371/journal.pmed.1001967},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014431},
}