@article{PAR00014427,
  title = {{A}ntiphospholipid antibody syndrome with valvular vegetations in acute {Q} fever},
  author = {{M}illion, {M}. and {T}huny, {F}. and {B}ardin, {N}. and {A}ngelakis, {E}. and {E}douard, {S}. and {B}essis, {S}. and {G}uimard, {T}. and {W}eitten, {T}. and {M}artin-{B}arbaz, {F}. and {T}exereau, {M}. and {A}youz, {K}. and {P}rotopopescu, {C}. and {C}arrieri, {P}. and {H}abib, {G}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {C}oxiella burnetii endocarditis is considered to be a late complication of {Q} fever in patients with preexisting valvular heart disease ({VHD}). {W}e observed a large transient aortic vegetation in a patient with acute {Q} fever and high levels of {I}g{G} anticardiolipin antibodies ({I}g{G} a{CL}). {T}herefore, we sought to determine how commonly acute {Q} fever could cause valvular vegetations associated with antiphospholipid antibody syndrome, which would be a new clinical entity. {M}ethods. {W}e performed a consecutive case series between {J}anuary 2007 and {A}pril 2014 at the {F}rench {N}ational {R}eferral {C}enter for {Q} fever. {A}ge, sex, history of {VHD}, immunosuppression, and {I}g{G} a{CL} assessed by enzyme-linked immunosorbent assay were tested as potential predictors. {R}esults. {O}f the 759 patients with acute {Q} fever and available echocardiographic results, 9 (1.2%) were considered to have acute {Q} fever endocarditis, none of whom had a previously known {VHD}. {A}fter multiple adjustment, very high {I}g{G} a{CL} levels (>100 immunoglobulin {G}-type phospholipid units; relative risk [{RR}], 24.9 [95% confidence interval {{CI}}, 4.5-140.2]; {P} = .002) and immunosuppression ({RR}, 10.1 [95% {CI}, 3.0-32.4]; {P} = .002) were independently associated with acute {Q} fever endocarditis. {C}onclusions. {A}ntiphospholipid antibody syndrome with valvular vegetations in acute {Q} fever is a new clinical entity. {T}his would suggest the value of systematically testing for {C}. burnetii in antiphospholipid-associated cardiac valve disease, and performing early echocardiography and antiphospholipid dosages in patients with acute {Q} fever.},
  keywords = {{Q} fever ; {C}oxiella burnetii ; antiphospholipid antibodies ; valvular heart ; disease ; {FRANCE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {62},
  numero = {5},
  pages = {537--544},
  ISSN = {1058-4838},
  year = {2016},
  DOI = {10.1093/cid/civ956},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014427},
}