@article{PAR00014420,
  title = {{P}atterns of {K}ingella kingae disease outbreaks},
  author = {{E}l {H}oumami, {N}. and {M}inodier, {P}. and {D}ubourg, {G}. and {M}irand, {A}. and {J}ouve, {J}. {L}. and {B}asmaci, {R}. and {C}harrel, {R}. and {B}onacorsi, {S}. and {Y}agupsky, {P}. and {R}aoult, {D}idier and {F}ournier, {P}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {K}ingella kingae outbreaks occur sporadically in childcare centers but remain poorly understood and difficult to identify. {M}ethods: {T}o provide the basis of a better knowledge of {K}. kingae outbreaks patterns that may help to guide identification and management strategies, we collected epidemiological, clinical and laboratory data from all reported {K}. kingae outbreaks, and those from 2 new {I}srael outbreaks in 2014. {R}esults: {N}ine outbreaks were identified in the {USA}, {I}srael and {F}rance from 2003 to 2014. {T}wenty-seven children with a median age of 14 +/- 4.1 months were affected, male:female ratio of 1.4:1. {O}utbreaks demonstrated seasonal patterns from the 10th to the 45th weeks, a mean duration of 13.1 +/- 8.4 days, a mean attack rate of 17.3 +/- 5.1% and a case-fatality rate of 3.7% (1/27). {S}eventy-four percentage of children had fever (20/27), and the mean values of white blood cell count and {C}-reactive protein level were 14.6 +/- 4.5 x 10(9)/{L} and 23.8 +/- 24.1 mg/{L}, respectively. {O}steoarticular infections accounted for 88.9% of cases (24/27), bacteremia 7.4% (2/27), endocarditis 3.7% (1/27) and meningitis 3.7% (1/27). {S}pecific real-time polymerase chain reaction demonstrated higher performance than culture methods in the diagnosis of case patients and investigations of oropharyngeal {K}. kingae carriage among close contacts, and multilocus sequence typing methods revealed that {ST}-6 and {ST}-25 invasive strains were responsible for multiple country-dependent outbreaks. {C}oviral infections were identified in the majority of {K}. kingae outbreaks, notably those causing oral ulcers. {C}onclusions: {K}. kingae outbreaks displayed severe {K}. kingae diseases that were poorly confirmed with culture methods. {W}e argue for the use of genomic technologies to investigate further {K}. kingae outbreaks.},
  keywords = {foot, and mouth disease ; public health ; osteoarticular infections ; {K}ingella kingae ; hand ; {MLST} ; outbreak ; {ISRAEL}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {35},
  numero = {3},
  pages = {340--346},
  ISSN = {0891-3668},
  year = {2016},
  DOI = {10.1097/inf.0000000000001010},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014420},
}