@article{PAR00014193,
  title = {{D}oxycycline assay hair samples for testing long-term compliance treatment},
  author = {{A}ngelakis, {E}. and {A}rmstrong, {N}. and {N}appez, {C}. and {R}ichez, {M}. and {C}habri{\`e}re, {E}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {M}any patients undergoing long-term doxycycline treatment do not regularly take their treatment because of photosensitivity. {O}ur objective was to create an assay for determining doxycycline levels and to use hair samples for monitoring the compliance over a longer period of time. {M}ethods: {W}e tested sera and hair samples from patients treated with doxycycline by a suitable ultra-high performance liquid chromatography ({UHPLC}) based assay. {R}esults: {W}e estimated that the speed of hair growth is roughly 1.25 cm per month and we were able to determine doxycycline levels over a 6-month period. {W}e tested 14 patients treated with doxycycline and we found similar levels of doxycycline in the serum and the hair samples representing the last 4 months. {L}inear regression analysis revealed that the level of doxycycline in the serum remained stable over time (p = 0.7) but the level of doxycycline in the hair decreased significantly over time (p = 0.03) indicating a degradation of this molecule in the hair. {W}e detected two patients who did not have antibiotic in the hair, indicating a lack of compliance that was also confirmed by interview. {C}onclusion: {H}air samples can be used to test long-term compliance in patients to explain failures or relapses.},
  keywords = {{D}oxycycline ; {U}ltra-high performance liquid chromatography ; {H}air samples ; {C}ompliance ; {Q} fever ; {W}hipple's disease},
  booktitle = {},
  journal = {{J}ournal of {I}nfection},
  volume = {71},
  numero = {5},
  pages = {511--517},
  ISSN = {0163-4453},
  year = {2015},
  DOI = {10.1016/j.jinf.2015.08.003},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014193},
}