@article{PAR00014188,
  title = {{E}merging methodologies for pathogen identification in positive blood culture testing},
  author = {{D}ubourg, {G}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}loodstream infections ({BSI}s) represent a major cause of death in developed countries and are associated with long-term loss of functions. {B}lood culture remains the gold standard for {BSI} diagnosis, as it is easy to perform and displays a good analytical sensitivity. {H}owever, its major drawback remains the long turnaround time, which can result in inappropriate therapy, fall of survival rate, emergence of antibiotic resistance and increase of medical costs. {O}ver the last 10years, molecular tools have been the alternative to blood cultures, allowing early identification of pathogens involved in sepsis, as well detection of critical antibiotic resistance genes. {B}esides, the advent of {MALDI}-{TOF} revolutionized practice in routine microbiology significantly reduced the time to result. {R}eviewed here are recent improvements in early {BSI} diagnosis and these authors' view for the future is presented, including innovative high-throughput technologies.},
  keywords = {{B}lood culture ; bloodstream infections ; {MALDI}-{TOF} {MS} ; multiplex {PCR} ; next-generation sequencing ; {NGS} ; {PCR} {ESI}-{MS}},
  booktitle = {},
  journal = {{E}xpert {R}eview of {M}olecular {D}iagnostics},
  volume = {16},
  numero = {1},
  pages = {97--111},
  ISSN = {1473-7159},
  year = {2016},
  DOI = {10.1586/14737159.2016.1112274},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00014188},
}