%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vouga, M.
%A Diabi, H.
%A Boulos, A.
%A Baud, D.
%A Raoult, Didier
%A Greub, G.
%T Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae
%D 2015
%L PAR00013947
%G ENG
%J Microbes and Infection
%@ 1286-4579
%K Parachlamydiaceae ; Antibiotic ; Pneumonia ; Chlamydia ; Intracellular bacteria
%M ISI:000365593600009
%N 11-12
%P 761-765
%R 10.1016/j.micinf.2015.08.002
%U https://www.documentation.ird.fr/hor/PAR00013947
%V 17
%W Horizon (IRD)
%X Parachlamydia acanthamoebae and Neochlamydia hartmanellae are Chlamydia-related bacteria naturally infecting free-living amoebae. These strict intracellular bacteria might represent emerging pathogens. Recent studies report an association with lower respiratory tract infections, especially with pneumonia where they have been identified as a potential causative agent in 1-2% of cases. In this study, we defined the antibiotic susceptibility of N. hartmanellae, two strains of P. acanthamoebae and two yet unclassified Parachlamydiaceae strains using a quantitative approach. We confirmed the results obtained earlier for P. acanthamoebae strain Bn9 in an observational study. Macrolides (MICs < 0.06-0.5 mu g/ml), rifampicin (MICs 0.25-2) and doxycycline (2-4 mu g/ml) were active against P. acanthamoebae strains and Neochlamydia. All strains were resistant to amoxicillin, ceftriaxone and imipenem (MIC >= 32 mu g/ml). Similarly to other Chlamydia-related bacteria, all investigated Parachlamydiaceae were resistant to quinolones (MICs >= 16 mu g/ml). Therefore, we recommend a treatment with macrolides for Parachlamydia-associated pneumonia.
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