Vouga M., Diabi H., Boulos A., Baud D., Raoult Didier, Greub G. (2015). Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae. Microbes and Infection, 17 (11-12), p. 761-765. ISSN 1286-4579.
Titre du document
Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae
Vouga M., Diabi H., Boulos A., Baud D., Raoult Didier, Greub G.
Source
Microbes and Infection, 2015,
17 (11-12), p. 761-765 ISSN 1286-4579
Parachlamydia acanthamoebae and Neochlamydia hartmanellae are Chlamydia-related bacteria naturally infecting free-living amoebae. These strict intracellular bacteria might represent emerging pathogens. Recent studies report an association with lower respiratory tract infections, especially with pneumonia where they have been identified as a potential causative agent in 1-2% of cases. In this study, we defined the antibiotic susceptibility of N. hartmanellae, two strains of P. acanthamoebae and two yet unclassified Parachlamydiaceae strains using a quantitative approach. We confirmed the results obtained earlier for P. acanthamoebae strain Bn9 in an observational study. Macrolides (MICs < 0.06-0.5 mu g/ml), rifampicin (MICs 0.25-2) and doxycycline (2-4 mu g/ml) were active against P. acanthamoebae strains and Neochlamydia. All strains were resistant to amoxicillin, ceftriaxone and imipenem (MIC >= 32 mu g/ml). Similarly to other Chlamydia-related bacteria, all investigated Parachlamydiaceae were resistant to quinolones (MICs >= 16 mu g/ml). Therefore, we recommend a treatment with macrolides for Parachlamydia-associated pneumonia.
