Publications des scientifiques de l'IRD

Chawech R., Jarraya R., Girardi C., Vansteelandt M., Marti G., Nasri I., Racaud-Sultan C., Fabre Nicolas. (2015). Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. Molecules, 20 (10), p. 18001-18015. ISSN 1420-3049.

Titre du document
Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000364231200019
Auteurs
Chawech R., Jarraya R., Girardi C., Vansteelandt M., Marti G., Nasri I., Racaud-Sultan C., Fabre Nicolas
Source
Molecules, 2015, 20 (10), p. 18001-18015 ISSN 1420-3049
Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010081648]
Identifiant IRD
PAR00013935
Contact