@article{PAR00013734,
  title = {{P}an-genomic analysis to redefine species and subspecies based on quantum discontinuous variation : the {K}lebsiella paradigm},
  author = {{C}aputo, {A}. and {M}erhej, {V}. and {G}eorgiades, {K}. and {F}ournier, {P}. {E}. and {C}roce, {O}. and {R}obert, {C}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {V}arious methods are currently used to define species and are based on the phylogenetic marker 16{S} ribosomal {RNA} gene sequence, {DNA}-{DNA} hybridization and {DNA} {GC} content. {H}owever, these are restricted genetic tools and showed significant limitations. {R}esults: {I}n this work, we describe an alternative method to build taxonomy by analyzing the pan-genome composition of different species of the {K}lebsiella genus. {K}lebsiella species are {G}ram-negative bacilli belonging to the large {E}nterobacteriaceae family. {I}nterestingly, when comparing the core/pan-genome ratio; we found a clear discontinuous variation that can define a new species. {C}onclusions: {U}sing this pan-genomic approach, we showed that {K}lebsiella pneumoniae subsp. ozaenae and {K}lebsiella pneumoniae subsp. rhinoscleromatis are species of the {K}lebsiella genus, rather than subspecies of {K}lebsiella pneumoniae. {T}his pan-genomic analysis, helped to develop a new tool for defining species introducing a quantic perspective for taxonomy.},
  keywords = {{P}an-genome ; {K}lebsiella pneumoniae ; {T}axonomy},
  booktitle = {},
  journal = {{B}iology {D}irect},
  volume = {10},
  numero = {},
  pages = {art. 55},
  ISSN = {1745-6150},
  year = {2015},
  DOI = {10.1186/s13062-015-0085-2},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00013734},
}