%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A D'Amato, F.
%A Eldin, C.
%A Georgiades, K.
%A Edouard, S.
%A Delerce, J.
%A Labas, N.
%A Raoult, Didier
%T Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana
%D 2015
%L PAR00013618
%G ENG
%J Comparative Immunology Microbiology and Infectious Diseases
%@ 0147-9571
%K Coxiella burnetii ; Guiana ; Cb175
%K GUYANE FRANCAISE
%M ISI:000359297900005
%P 35-41
%R 10.1016/j.cimid.2015.04.003
%U https://www.documentation.ird.fr/hor/PAR00013618
%V 41
%W Horizon (IRD)
%X In French Guiana, the unique Coxiella burneta circulating genotype 17 causes 24% of community-acquired pneumonia, the highest prevalence ever described. To explain this unusual virulence, we performed a comparative genomic analysis of strain Cb175, which was isolated from a patient from French Guiana. Cb175 has a greater number of mutations in genes involved in metabolism compared with the Nine Mile I strain. We found a 6105 bp fragment missing in Cb175, which corresponds to the Type 1 secretion systems (T1SS) hlyCABD operon region. This deletion was detected by a specific qPCR in the 8 other strains available from this territory an in none of 298 C.burnetii strains from other areas and other genotypes (8/8 vs 0/298, Fisher's exact test, p < 0.0000001). Loss of genes implicated in secretion systems has been observed in other epidemic bacterial strains. Thus, the virulence of Cb175 may be linked to this genome reduction.
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