@article{PAR00013618,
  title = {{L}oss of {TSS}1 in hypervirulent {C}oxiella burnetii 175, the causative agent of {Q} fever in {F}rench {G}uiana},
  author = {{D}'{A}mato, {F}. and {E}ldin, {C}. and {G}eorgiades, {K}. and {E}douard, {S}. and {D}elerce, {J}. and {L}abas, {N}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n {F}rench {G}uiana, the unique {C}oxiella burneta circulating genotype 17 causes 24% of community-acquired pneumonia, the highest prevalence ever described. {T}o explain this unusual virulence, we performed a comparative genomic analysis of strain {C}b175, which was isolated from a patient from {F}rench {G}uiana. {C}b175 has a greater number of mutations in genes involved in metabolism compared with the {N}ine {M}ile {I} strain. {W}e found a 6105 bp fragment missing in {C}b175, which corresponds to the {T}ype 1 secretion systems ({T}1{SS}) hly{CABD} operon region. {T}his deletion was detected by a specific q{PCR} in the 8 other strains available from this territory an in none of 298 {C}.burnetii strains from other areas and other genotypes (8/8 vs 0/298, {F}isher's exact test, p < 0.0000001). {L}oss of genes implicated in secretion systems has been observed in other epidemic bacterial strains. {T}hus, the virulence of {C}b175 may be linked to this genome reduction.},
  keywords = {{C}oxiella burnetii ; {G}uiana ; {C}b175 ; {GUYANE} {FRANCAISE}},
  booktitle = {},
  journal = {{C}omparative {I}mmunology {M}icrobiology and {I}nfectious {D}iseases},
  volume = {41},
  numero = {},
  pages = {35--41},
  ISSN = {0147-9571},
  year = {2015},
  DOI = {10.1016/j.cimid.2015.04.003},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00013618},
}