@article{PAR00013369,
  title = {{C}ommon occurrence of antibacterial agents in human intestinal microbiota},
  author = {{D}rissi, {F}. and {B}uffet, {S}. and {R}aoult, {D}idier and {M}erhej, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}aboratory experiments have revealed many active mechanisms by which bacteria can inhibit the growth of other organisms. {B}acteriocins are a diverse group of natural ribosomally synthesized antimicrobial peptides produced by a wide range of bacteria and which seem to play an important role in mediating competition within bacterial communities. {I}n this study, we have identified and established the structural classification of putative bacteriocins encoded by 317 microbial genomes in the human intestine. {O}n the basis of homologies to available bacteriocin sequences, mainly from lactic acid bacteria, we report the widespread occurrence of bacteriocins across the gut microbiota: 175 bacteriocins were found to be encoded in {F}irmicutes, 79 in {P}roteobacteria, 34 in {B}acteroidetes, and 25 in {A}ctinobacteria. {B}acteriocins from gut bacteria displayed wide differences among phyla with regard to class distribution, net positive charge, hydrophobicity and secondary structure, but the a-helix was the most abundant structure. {T}he peptide structures and physiochemical properties of bacteriocins produced by the most abundant bacteria in the gut, the {F}irmicutes and the {B}acteroidetes, seem to ensure low antibiotic activity and participate in permanent intestinal host defense against the proliferation of harmful bacteria. {M}eanwhile, the potentially harmful bacteria, including the {P}roteobacteria, displayed highly effective bacteriocins, probably supporting the virulent character of diseases. {T}hese findings highlight the eventual role played by bacteriocins in gut microbial competition and their potential place in antibiotic therapy.},
  keywords = {bacteriocin ; antimicrobial peptides ; microbiota ; gastrointestinal tract ; {BUR} database},
  booktitle = {},
  journal = {{F}rontiers in {M}icrobiology},
  volume = {6},
  numero = {},
  pages = {art. 441 [8 p.]},
  ISSN = {1664-302{X}},
  year = {2015},
  DOI = {10.3389/fmicb.2015.00441},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00013369},
}